Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum

The diagnosis of smear-negative or sputum-scarce tuberculosis (TB) is problematic as culture takes several weeks and representative biological samples are difficult to obtain. RD-1 antigen-specific interferon-gamma release assays (IGRAs) are sensitive and specific blood-based tests for the diagnosis...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e10389-e10389
Hauptverfasser:	Cashmore, Tamaryn J, Peter, Jonathan G, van Zyl-Smit, Richard N, Semple, Patricia L, Maredza, Alice, Meldau, Richard, Zumla, Alimuddin, Nurse, Barbara, Dheda, Keertan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens Assaying Biological properties Biological samples Case-Control Studies Cell culture Coculture Techniques Diagnosis Diagnostic systems Enzyme-Linked Immunosorbent Assay Enzymes ESAT-6 antigen Feasibility Feasibility Studies Female Humans Immunodiagnosis Immunologic Tests - methods Immunology Immunology/Immune Response Immunology/Immunomodulation Immunology/Leukocyte Activation Infections Infectious diseases Infectious Diseases/Bacterial Infections Infectious Diseases/Respiratory Infections Interferon Interferon-gamma - analysis Interferon-gamma - immunology Laboratories Male Medical diagnosis Medicine Meningitis Microscopy Middle Aged Optimization Patients Smear Spots Sputum T cell receptors Tuberculosis Tuberculosis - diagnosis Young Adult γ-Interferon
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