Structural and functional characterization of human peripheral nervous system myelin protein P2

The myelin sheath is a tightly packed multilayered membrane structure insulating selected axons in the central and the peripheral nervous systems. Myelin is a biochemically unique membrane, containing a specific set of proteins. In this study, we expressed and purified recombinant human myelin P2 pr...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e10300
Hauptverfasser:	Majava, Viivi, Polverini, Eugenia, Mazzini, Alberto, Nanekar, Rahul, Knoll, Wiebke, Peters, Judith, Natali, Francesca, Baumgärtel, Peter, Kursula, Inari, Kursula, Petri
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Axons Biochemistry Biochemistry/Biomacromolecule-Ligand Interactions Biochemistry/Macromolecular Assemblies and Machines Biochemistry/Macromolecular Chemistry Biochemistry/Protein Folding Biophysics/Protein Chemistry and Proteomics Cholesterol Cloning Crystal structure Crystallography, X-Ray Deoxyribonucleic acid DNA Docking Electron density Electrostatic properties Enzymes Fatty acids Fluorescence Fluorescence spectroscopy Humans Immunoglobulins Ligands Lipids Lymphocytes Membrane structure Membranes Models, Molecular Molecular Biology Myelin Myelin P2 Protein - chemistry Myelin P2 Protein - physiology Myelin Sheath - chemistry Nervous system Neurological Disorders/Multiple Sclerosis and Related Disorders Neurological Disorders/Peripheral Neuropathies Palmitic acid Palmitic Acid - chemistry Particle accelerators Peripheral nervous system Peripheral Nervous System - chemistry Plasmids Polyethylene glycol Protein Binding Protein Conformation Protein structure Proteins Radiation Solutions Spectrometry, Fluorescence Spectroscopy Sterols Structural analysis Structure-function relationships Synchrotron radiation Synchrotrons Topography
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