Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo

The low-density lipoprotein (LDL) receptor gene family is a highly conserved group of membrane receptors with diverse functions in developmental processes, lipoprotein trafficking, and cell signaling. The low-density lipoprotein (LDL) receptor-related protein 1b (LRP1B) was reported to be deleted in...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e9960-e9960
Hauptverfasser:	Dietrich, Martin F, van der Weyden, Louise, Prosser, Haydn M, Bradley, Allan, Herz, Joachim, Adams, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Biochemistry/Cell Signaling and Trafficking Structures Blastocysts Cancer Cell Biology/Neuronal Signaling Mechanisms Cell culture Cells, Cultured Deoxyribonucleic acid Developmental Biology/Morphogenesis and Cell Biology DNA Embryogenesis Embryonic Development Embryonic growth stage Exons Gene Targeting Genetics Genomics Lethality Ligands Low density lipoprotein Low density lipoproteins LRP1B protein Lung cancer Lung diseases Mice Modulators Mutation N-Terminus Non-small cell lung cancer Non-small cell lung carcinoma Proteases Protein Structure, Tertiary Proteins Pseudomonas Receptor density Receptors Receptors, LDL - genetics Receptors, LDL - physiology Respiratory Medicine/Lung Cancer Rodents Secretase Signal Transduction Signaling Smooth muscle Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology Tumors Viability Wnt protein Wnt Proteins - metabolism
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