Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice

Mutations in the LMNA gene, which encodes all A-type lamins, result in a variety of human diseases termed laminopathies. Lmna(-/-) mice appear normal at birth but become runted as early as 2 weeks of age and develop multiple tissue defects that mimic some aspects of human laminopathies. Lmna(-/-) mi...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e10127-e10127
Hauptverfasser:	Hale, J Scott, Frock, Richard L, Mamman, Sara A, Fink, Pamela J, Kennedy, Brian K
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals B-Lymphocytes - cytology Biochemistry Bone marrow Cardiomyopathy CD4 antigen CD8 antigen Defects Developmental Biology/Cell Differentiation Disease Flow cytometry Genes Genetics and Genomics/Disease Models Genetics and Genomics/Nuclear Structure and Function Homeostasis Immunoglobulins Immunology Lamin Type A - deficiency Lamin Type A - genetics Lamins Lobes Lymphatic system Lymphocytes Lymphocytes - pathology Lymphocytes B Lymphocytes T Major histocompatibility complex Mice Mice, Knockout Muscular Dystrophies Musculoskeletal system Mutation Neonates Proteins Skeletal muscle Spleen Stem cells Stroma T-Lymphocytes - cytology Thymus Thymus Gland - cytology Transplantation
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