MAPK activation modulates permeability of isolated rat alveolar epithelial cell monolayers following cyclic stretch

We cultured (5 days) rat alveolar epithelial cells to investigate the role of mitogen-activated protein kinase (MAPk) signaling in ventilator induced epithelial barrier dysfunction. Cells were stretched to a magnitude of 12% or 37% change in surface area at a rate of 0.25 Hz with and without pretrea...

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Veröffentlicht in:	PloS one 2010-04, Vol.5 (4), p.e10385-e10385
Hauptverfasser:	Cohen, Taylor S, Gray Lawrence, Gladys, Khasgiwala, Amit, Margulies, Susan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animals Apoptosis Bioengineering Cell adhesion Cell adhesion & migration Cell Biology/Cell Signaling Cell Biology/Cellular Death and Stress Responses Cell growth Cell Shape Coronary vessels Epidermal growth factor Epithelial cells Epithelial Cells - cytology Extracellular signal-regulated kinase Inhibition Inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases MAP kinase MAP Kinase Signaling System - physiology Mechanical ventilation Membrane permeability Membrane Proteins - genetics Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - physiology Monolayers Monomolecular films Permeability Phosphorylation Pretreatment Protein kinase Protein kinases Proteins - genetics Pulmonary Alveoli - cytology Pulmonary Alveoli - metabolism Rats Respiratory Medicine/Sleep and Ventilation Disorders Rodents Signal Transduction - physiology Signaling Stress, Mechanical Studies Surface area Tight Junctions - chemistry Tracers (Biology) Ventilation
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