Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines

Cystatin C (CysC) expression in the brain is elevated in human patients with epilepsy, in animal models of neurodegenerative conditions, and in response to injury, but whether up-regulated CysC expression is a manifestation of neurodegeneration or a cellular repair response is not understood. This s...

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Veröffentlicht in:	PloS one 2010-03, Vol.5 (3), p.e9819-e9819
Hauptverfasser:	Tizon, Belen, Sahoo, Susmita, Yu, Haung, Gauthier, Sebastien, Kumar, Asok R, Mohan, Panaiyur, Figliola, Matthew, Pawlik, Monika, Grubb, Anders, Uchiyama, Yasuo, Bandyopadhyay, Urmi, Cuervo, Ana Maria, Nixon, Ralph A, Levy, Efrat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - metabolism Alzheimer's disease Alzheimers disease Analysis Animal models Animals Apoptosis Apoptosis Regulatory Proteins - metabolism Autophagy Basic Medicine Beclin-1 Brain Cathepsin B Cathepsins Cell Biology/Cellular Death and Stress Responses Cell death Cell Line Cell lines Colchicine Colchicine - pharmacology Cystatin C Cystatin C - metabolism Cysteine Cysteine proteinase Cytotoxicity Deprivation Enzyme Inhibitors - pharmacology Enzyme kinetics Epilepsy Farmakologi och toxikologi Hypotheses Ischemia Localization Lysosomes Lysosomes - metabolism Läkemedelskemi Medical and Health Sciences Medicin och hälsovetenskap Medicinal Chemistry Medicine Medicinska och farmaceutiska grundvetenskaper Mice Microscopy Molecular biology Nervous system diseases Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurological diseases Neurological Disorders/Alzheimer Disease Neuromodulation Neurons Neurons - metabolism Neuroprotection Neuroscience Neuroscience/Neurobiology of Disease and Regeneration Oxidative Stress Pathology Peptides Phagocytosis Pharmacology and Toxicology Protease inhibitors Proteins Proteolysis Rats Rats, Sprague-Dawley Rodents siRNA Staurosporine Staurosporine - pharmacology Stroke Substrate inhibition Substrates TOR protein TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tubulin Modulators - pharmacology Urine
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