WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans

Pore-forming toxins (PFTs) are the single largest class of bacterial virulence factors. The DAF-2 insulin/insulin-like growth factor-1 signaling pathway, which regulates lifespan and stress resistance in Caenorhabditis elegans, is known to mutate to resistance to pathogenic bacteria. However, its ro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2010-03, Vol.5 (3), p.e9494-e9494
Hauptverfasser:	Chen, Chang-Shi, Bellier, Audrey, Kao, Cheng-Yuan, Yang, Ya-Luen, Chen, Huan-Da, Los, Ferdinand C O, Aroian, Raffi V
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Ataxia Autophagy Bacillus thuringiensis - metabolism Bacteria Biochemistry Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Caenorhabditis elegans Proteins - physiology Cell Biology/Cell Signaling Cell Biology/Cellular Death and Stress Responses Cellular communication Developmental biology E coli Forming Gene Expression Regulation Genetics Genetics and Genomics/Animal Genetics Genetics and Genomics/Disease Models Gram-Positive Bacterial Infections - metabolism Humans Hypoxia Immunity Immunology/Immune Response Immunology/Innate Immunity Innate immunity Insulin Insulin - metabolism Insulin-like growth factor I Insulin-like growth factors Kinases Life span Medical research Microbial drug resistance Microbiology/Innate Immunity Models, Biological Molecular biology Mutation Nematodes Pathogenesis Phosphatase Pore formation Proteins Pseudomonas aeruginosa Receptor, Insulin - metabolism Respiration RNA Interference Signal Transduction Signaling Toxins Ubiquitin-Protein Ligases - metabolism Ubiquitin-Protein Ligases - physiology Virulence Virulence (Microbiology) Virulence Factors Worms
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!