Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel

Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesi...

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Veröffentlicht in:	PloS one 2010-03, Vol.5 (3), p.e9589-e9589
Hauptverfasser:	Teramoto, Takayuki, Sternick, Laura A, Kage-Nakadai, Eriko, Sajjadi, Shirine, Siembida, Jakub, Mitani, Shohei, Iwasaki, Kouichi, Lambie, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Cell Biology/Gene Expression Cells, Cultured Electrophysiology - methods Epithelial cells Excretion Excretory system Genetic Vectors Genetics and Genomics/Gene Function Genomes Homeostasis Intestine Ion Channels - metabolism Kidney - metabolism Liquefied gases Localization Magnesium Magnesium - metabolism Mammals Medicine Models, Biological Mutation Nematodes Neurons Physiology Physiology/Renal, Fluid, and Electrolyte Physiology Potassium - chemistry Proteins Reabsorption RNA Interference Spinal cord Trace Elements Transient receptor potential proteins TRPM Cation Channels - metabolism Worms
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