Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis

Left-right asymmetry in vertebrates is initiated in an early embryonic structure called the ventral node in human and mouse, and the gastrocoel roof plate (GRP) in the frog. Within these structures, each epithelial cell bears a single motile cilium, and the concerted beating of these cilia produces...

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Veröffentlicht in:	PloS one 2010-02, Vol.5 (2), p.e8999-e8999
Hauptverfasser:	Antic, Dragana, Stubbs, Jennifer L, Suyama, Kaye, Kintner, Chris, Scott, Matthew P, Axelrod, Jeffrey D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animals Asymmetry Attitude (inclination) Bioengineering Body Patterning - genetics Body Patterning - physiology Carrier Proteins - genetics Carrier Proteins - physiology Cell Biology Cell division Cell Line Cell migration Cell Polarity Cell surface Cilia Cilia - metabolism Cilia - physiology Conservation Defects Departments Developmental biology Developmental Biology/Embryology Developmental Biology/Morphogenesis and Cell Biology Drosophila Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - physiology Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - physiology Embryogenesis Embryonic development Embryonic growth stage Embryos Epithelial cells Evolutionary conservation Female Fluid dynamics Fluid flow Fluid mechanics Gene expression Gene Expression Regulation, Developmental Genetics Hemispheric laterality In Situ Hybridization Insects Laboratories LIM Domain Proteins Localization Male Mammals Medicine Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Morphogenesis Phenotypes Plates (structural members) Polarity Proteins Vertebrates Xenopus Xenopus laevis
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