CXCR7 functions as a scavenger for CXCL12 and CXCL11

CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signali...

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Veröffentlicht in:	PloS one 2010-02, Vol.5 (2), p.e9175-e9175
Hauptverfasser:	Naumann, Ulrike, Cameroni, Elisabetta, Pruenster, Monika, Mahabaleshwar, Harsha, Raz, Erez, Zerwes, Hans-Günter, Rot, Antal, Thelen, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animal tissues Animals B cells Biochemistry Biochemistry/Cell Signaling and Trafficking Structures Biomedical research Bone marrow Cell adhesion & migration Cell Biology Cell Biology/Membranes and Sorting Cell Line Cell Line, Tumor Cell Membrane - metabolism Cells, Cultured Chemokine CXCL11 - genetics Chemokine CXCL11 - metabolism Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemokine receptors Chemokines CXCL11 protein CXCL12 protein CXCR4 protein Danio rerio Degradation Embryo, Nonmammalian - metabolism Embryos Endocytosis - physiology Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium Female Flow Cytometry Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Heart HeLa Cells Human tissues Humans Immunology Immunology/Immunomodulation Internalization Kinases Ligands Male Mammalian cells Mammals Metastasis Mice Mice, Inbred BALB C Microscopy, Confocal Mutation Myocardium - metabolism Organs Penicillin Phylogeny Plasmids Prostate cancer Proteins Receptors Receptors, CXCR - genetics Receptors, CXCR - metabolism Receptors, CXCR - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Rodents Scavenger receptors Signal transduction Signaling Transfection Umbilical vein Zebrafish
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