Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects
Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. T...
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| description | Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. The effects of trans fatty acids from ruminants are less clear. We investigated the effect on blood lipids of cis-9, trans-11 conjugated linoleic acid (CLA), a trans fatty acid largely restricted to ruminant fats.
Sixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (+/- SD) serum LDL cholesterol was 2.68+/-0.62 mmol/L compared to 3.00+/-0.66 mmol/L after industrial trans fatty acids (p |
| doi_str_mv | 10.1371/journal.pone.0009000 |
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Sixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (+/- SD) serum LDL cholesterol was 2.68+/-0.62 mmol/L compared to 3.00+/-0.66 mmol/L after industrial trans fatty acids (p<0.001), and 2.92+/-0.70 mmol/L after CLA (p<0.001). Compared to oleic acid, HDL-cholesterol was 0.05+/-0.12 mmol/L lower after industrial trans fatty acids (p = 0.001) and 0.06+/-0.10 mmol/L lower after CLA (p<0.001). The total-to-HDL cholesterol ratio was 11.6% higher after industrial trans fatty acids (p<0.001) and 10.0% higher after CLA (p<0.001) relative to the oleic acid diet.
High intakes of an 80:20 mixture of cis-9, trans-11 and trans-10, cis-12 CLA raise the total to HDL cholesterol ratio in healthy volunteers. The effect of CLA may be somewhat less than that of industrial trans fatty acids.
ClinicalTrials.gov NCT00529828.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0009000</identifier><identifier>PMID: 20140250</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Apolipoproteins B - blood ; Blood cholesterol ; blood-lipids ; Body Weight - drug effects ; body-composition ; Cardiovascular diseases ; Cardiovascular Disorders ; cardiovascular-disease ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Coronary artery disease ; Coronary heart disease ; Cross-Over Studies ; Diarrhea - chemically induced ; Diet ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; Dietary Fats - pharmacology ; Fats ; Fatty acids ; Feeds ; Female ; hdl cholesterol ; Health risks ; Heart ; Heart diseases ; High cholesterol diet ; High density lipoprotein ; high-density ; Humans ; Hydrogenation ; Linoleic acid ; Linoleic Acids, Conjugated - administration & dosage ; Linoleic Acids, Conjugated - adverse effects ; Linoleic Acids, Conjugated - pharmacology ; lipid-metabolism ; Lipids ; Lipids - blood ; Low density lipoprotein ; Low density lipoproteins ; Male ; Medical research ; Middle Aged ; middle-aged men ; Monounsaturated fatty acids ; Nausea - chemically induced ; Nutrition ; Oleic acid ; Public Health and Epidemiology/Preventive Medicine ; Rodents ; Rumen ; Sex Factors ; Sheep ; Studies ; supplementation ; Time Factors ; Trans fatty acids ; Young Adult</subject><ispartof>PloS one, 2010-02, Vol.5 (2), p.e9000</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Wanders et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Wanders et al. 2010</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c852t-efd1628752f360a2e1388a1abc62a8f142c82fdf1ec9c7be0982383e3e466f0f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815780/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815780/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20140250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tomé, Daniel</contributor><creatorcontrib>Wanders, A.J</creatorcontrib><creatorcontrib>Brouwer, I.A</creatorcontrib><creatorcontrib>Siebelink, E</creatorcontrib><creatorcontrib>Katan, M.B</creatorcontrib><title>Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. The effects of trans fatty acids from ruminants are less clear. We investigated the effect on blood lipids of cis-9, trans-11 conjugated linoleic acid (CLA), a trans fatty acid largely restricted to ruminant fats.
Sixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (+/- SD) serum LDL cholesterol was 2.68+/-0.62 mmol/L compared to 3.00+/-0.66 mmol/L after industrial trans fatty acids (p<0.001), and 2.92+/-0.70 mmol/L after CLA (p<0.001). Compared to oleic acid, HDL-cholesterol was 0.05+/-0.12 mmol/L lower after industrial trans fatty acids (p = 0.001) and 0.06+/-0.10 mmol/L lower after CLA (p<0.001). The total-to-HDL cholesterol ratio was 11.6% higher after industrial trans fatty acids (p<0.001) and 10.0% higher after CLA (p<0.001) relative to the oleic acid diet.
High intakes of an 80:20 mixture of cis-9, trans-11 and trans-10, cis-12 CLA raise the total to HDL cholesterol ratio in healthy volunteers. The effect of CLA may be somewhat less than that of industrial trans fatty acids.
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administration & dosage</subject><subject>Linoleic Acids, Conjugated - adverse effects</subject><subject>Linoleic Acids, Conjugated - pharmacology</subject><subject>lipid-metabolism</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>middle-aged men</subject><subject>Monounsaturated fatty acids</subject><subject>Nausea - chemically induced</subject><subject>Nutrition</subject><subject>Oleic acid</subject><subject>Public Health and Epidemiology/Preventive Medicine</subject><subject>Rodents</subject><subject>Rumen</subject><subject>Sex Factors</subject><subject>Sheep</subject><subject>Studies</subject><subject>supplementation</subject><subject>Time Factors</subject><subject>Trans fatty acids</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21v0zAQxyMEYmPwDXiIhITEixY_JI7NC6RqGrRSxSQGvLUcx05dUjvYzsa-PW6bTa0ECEWJT3e_-_t88WXZcwimEFfw3doN3opu2jurpgAAlt4H2SlkGE0IAvjhgX2SPQlhDUCJKSGPsxMEYAFQCU4zeaG1kjF3Ohf53LSrfGGj-KG2jnNn10MromrypbGuU0bmM2ma3Nnk6F3vXVQm2epadSFP1lyJLq5u8_mwETa_Gup10g5Ps0dadEE9G9ez7NvHi6_n88ny8tPifLacSFqiOFG6gQTRqkQaEyCQgphSAUUtCRJUwwJJinSjoZJMVrUCjCJMscKqIEQDjc-yV3vdvnOBj_0JHCLKUMlKViRisScaJ9a892Yj_C13wvCdw_mWCx-N7BRnCOm0S12TsigKSVIhhDIBmNZVQxBKWu_3WjeiVdbY9OFWeGnCTrAztd-K3wye22679EMdOKYMM5ySP4ylDvVGNVLZ6EV3VNFxxJoVb901RxSWFQVJ4PUo4N3PQYX4l_OOVCvSkYzVLonJjQmSz4oKMwQQqhI1_QOVnkZtjEzXS5vkP0p4e5SQmKh-xVYMIfDF1Zf_Zy-_H7NvDtjV7jIF1w3ROBuOwWIPSu9C8Erfdw4Cvp2Ou27w7XTwcTpS2svDrt8n3Y1DAl7sAS0cF61P__LzMkXTriWC-B9xwEpS4t9o7Rvv</recordid><startdate>20100203</startdate><enddate>20100203</enddate><creator>Wanders, A.J</creator><creator>Brouwer, I.A</creator><creator>Siebelink, E</creator><creator>Katan, M.B</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>QVL</scope><scope>DOA</scope></search><sort><creationdate>20100203</creationdate><title>Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects</title><author>Wanders, A.J ; Brouwer, I.A ; Siebelink, E ; Katan, M.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c852t-efd1628752f360a2e1388a1abc62a8f142c82fdf1ec9c7be0982383e3e466f0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Apolipoproteins B - 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Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. The effects of trans fatty acids from ruminants are less clear. We investigated the effect on blood lipids of cis-9, trans-11 conjugated linoleic acid (CLA), a trans fatty acid largely restricted to ruminant fats.
Sixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (+/- SD) serum LDL cholesterol was 2.68+/-0.62 mmol/L compared to 3.00+/-0.66 mmol/L after industrial trans fatty acids (p<0.001), and 2.92+/-0.70 mmol/L after CLA (p<0.001). Compared to oleic acid, HDL-cholesterol was 0.05+/-0.12 mmol/L lower after industrial trans fatty acids (p = 0.001) and 0.06+/-0.10 mmol/L lower after CLA (p<0.001). The total-to-HDL cholesterol ratio was 11.6% higher after industrial trans fatty acids (p<0.001) and 10.0% higher after CLA (p<0.001) relative to the oleic acid diet.
High intakes of an 80:20 mixture of cis-9, trans-11 and trans-10, cis-12 CLA raise the total to HDL cholesterol ratio in healthy volunteers. The effect of CLA may be somewhat less than that of industrial trans fatty acids.
ClinicalTrials.gov NCT00529828.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20140250</pmid><doi>10.1371/journal.pone.0009000</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1289259594 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Apolipoproteins B - blood Blood cholesterol blood-lipids Body Weight - drug effects body-composition Cardiovascular diseases Cardiovascular Disorders cardiovascular-disease Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Coronary artery disease Coronary heart disease Cross-Over Studies Diarrhea - chemically induced Diet Dietary Fats - administration & dosage Dietary Fats - adverse effects Dietary Fats - pharmacology Fats Fatty acids Feeds Female hdl cholesterol Health risks Heart Heart diseases High cholesterol diet High density lipoprotein high-density Humans Hydrogenation Linoleic acid Linoleic Acids, Conjugated - administration & dosage Linoleic Acids, Conjugated - adverse effects Linoleic Acids, Conjugated - pharmacology lipid-metabolism Lipids Lipids - blood Low density lipoprotein Low density lipoproteins Male Medical research Middle Aged middle-aged men Monounsaturated fatty acids Nausea - chemically induced Nutrition Oleic acid Public Health and Epidemiology/Preventive Medicine Rodents Rumen Sex Factors Sheep Studies supplementation Time Factors Trans fatty acids Young Adult |
| title | Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T03%3A16%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20a%20High%20Intake%20of%20Conjugated%20Linoleic%20Acid%20on%20Lipoprotein%20Levels%20in%20Healthy%20Human%20Subjects&rft.jtitle=PloS%20one&rft.au=Wanders,%20A.J&rft.date=2010-02-03&rft.volume=5&rft.issue=2&rft.spage=e9000&rft.pages=e9000-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0009000&rft_dat=%3Cgale_plos_%3EA473920227%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1289259594&rft_id=info:pmid/20140250&rft_galeid=A473920227&rft_doaj_id=oai_doaj_org_article_922fc7bbb65444c6a1a689a09ff7d622&rfr_iscdi=true |