High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy

Immunotherapy based on natural killer (NK) cell infusions is a potential adjuvant treatment for many cancers. Such therapeutic application in humans requires large numbers of functional NK cells that have been selected and expanded using clinical grade protocols. We established an extremely efficien...

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Veröffentlicht in:	PloS one 2010-02, Vol.5 (2), p.e9221-e9221
Hauptverfasser:	Spanholtz, Jan, Tordoir, Marleen, Eissens, Diana, Preijers, Frank, van der Meer, Arnold, Joosten, Irma, Schaap, Nicolaas, de Witte, Theo M, Dolstra, Harry
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - immunology Biotechnology Blood Cancer Cancer immunotherapy Cancer treatment CD3 antigen CD34 antigen CD56 antigen CD56 Antigen - immunology Cell culture Cell Differentiation - immunology Cell Line, Tumor Cell Proliferation Cells (biology) Cells, Cultured Cord blood Cytokines Cytolysis Cytotoxicity Cytotoxicity, Immunologic - immunology Drug therapy Enzyme-Linked Immunosorbent Assay Expansion Fetal Blood - cytology Flow Cytometry Functional analysis Health aspects Hematology Hematology/Acute Myeloid Leukemia Hematology/Hematopoiesis Hematopoietic stem cells Humans Identification Immunoglobulin-like receptors Immunology Immunology/Innate Immunity Immunophenotyping Immunotherapy Immunotherapy, Adoptive - methods Interferon-gamma - metabolism K562 Cells Kidney cancer Killer cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Laboratories Leukemia Leukemia - immunology Leukemia - pathology Life sciences Medicine Melanoma Melanoma - immunology Melanoma - pathology Methods Myeloid leukemia Natural killer cells Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy NKG2 antigen Progenitor cells Receptors Stem cells Stem Cells - cytology Stem Cells - immunology T cell receptors Time Factors Toxicity Transplants & implants Tumor cell lines Umbilical cord
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