Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage

The MYC protein controls cellular functions such as differentiation, proliferation, and apoptosis. In response to genotoxic agents, cells overexpressing MYC undergo apoptosis. However, the MYC-regulated effectors acting upstream of the mitochondrial apoptotic pathway are still unknown. In this study...

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Veröffentlicht in:	PloS one 2010-01, Vol.5 (1), p.e8924
Hauptverfasser:	Guerra, Lina, Albihn, Ami, Tronnersjö, Susanna, Yan, Qinzi, Guidi, Riccardo, Stenerlöw, Bo, Sterzenbach, Torsten, Josenhans, Christine, Fox, James G, Schauer, David B, Thelestam, Monica, Larsson, Lars-Gunnar, Henriksson, Marie, Frisan, Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animal and Dairy Science Animals Apoptosis Ataxia Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins Bacteria Bioengineering Biotechnology Breakage Cancer therapies Cell Biology/Cellular Death and Stress Responses Cell Biology/Chemical Biology of the Cell Cell cycle Cell Cycle Proteins - metabolism Cell death Cell differentiation Cell Division Cell growth Cell Line Cell lines Cell proliferation Cells (Biology) Cytolethal distending toxin Data processing Deoxyribonucleic acid Departments Differentiation DNA DNA Damage DNA-Binding Proteins - metabolism Effectors Epidemiology Gene Knockdown Techniques Genes, myc Genotoxicity Haemophilus ducreyi Histone H2A Husdjursvetenskap I.R. radiation Ionizing radiation Irradiation Kinases Lymphoma Lymphomas MEDICIN Medicin och hälsovetenskap MEDICINE Mitochondria Molecular biology Myc protein Nijmegen breakage syndrome Null cells Oncology/Oncology Agents Phosphorylation Physiology Protein-Serine-Threonine Kinases - metabolism Proteins Radiation Radiation damage Rats RNA, Small Interfering siRNA Tumor Suppressor Proteins - metabolism U.V. radiation Ultraviolet radiation Veterinary Science Veterinärmedicin
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