Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells
The availability of specific markers expressed in different regions of the developing nervous system provides a useful tool to illuminate their development, regulation and function. We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the...
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| creator | Uhde, Christopher W Vives, Joaquim Jaeger, Ines Li, Meng |
| description | The availability of specific markers expressed in different regions of the developing nervous system provides a useful tool to illuminate their development, regulation and function. We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the midbrain floor plate region, the isthmus and the roof plate of the anterior neural tube. At the developmental stage when the ventral dopaminergic neuron territory is being established, Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area that lies close to the ventral midline. Thus this study presents Rmst as a novel marker for the developing dopaminergic neurons in the mesencephalic floor plate as well as a marker for the dorsal midline cells of the anterior neural tube and the isthmic organizer. |
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We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the midbrain floor plate region, the isthmus and the roof plate of the anterior neural tube. At the developmental stage when the ventral dopaminergic neuron territory is being established, Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area that lies close to the ventral midline. Thus this study presents Rmst as a novel marker for the developing dopaminergic neurons in the mesencephalic floor plate as well as a marker for the dorsal midline cells of the anterior neural tube and the isthmic organizer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0008641</identifier><identifier>PMID: 20062813</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Base Sequence ; Biomarkers - metabolism ; Blotting, Northern ; Brain - embryology ; Brain - metabolism ; Coding ; Developmental Biology/Neurodevelopment ; DNA Primers ; Dopamine ; Dopamine receptors ; Floor plate ; Gene expression ; Genetics and Genomics/Gene Discovery ; Hybridization ; In Situ Hybridization ; Medicine ; Mesencephalon ; Mice ; Nervous system ; Neural tube ; Neurons ; Neuroscience/Neurodevelopment ; Non-coding RNA ; Phenols ; Ribonucleic acid ; RNA ; Spinal cord ; Studies ; Territory ; Ventral tegmentum</subject><ispartof>PloS one, 2010-01, Vol.5 (1), p.e8641-e8641</ispartof><rights>COPYRIGHT 2010 Public Library of Science</rights><rights>2010 Uhde et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Uhde et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c723t-154f7e90f8d06224c6e92a65b2dc40f1a0062d79f29c861afd2e7af28fad9bae3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799666/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799666/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20062813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Riley, Bruce</contributor><creatorcontrib>Uhde, Christopher W</creatorcontrib><creatorcontrib>Vives, Joaquim</creatorcontrib><creatorcontrib>Jaeger, Ines</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><title>Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The availability of specific markers expressed in different regions of the developing nervous system provides a useful tool to illuminate their development, regulation and function. We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the midbrain floor plate region, the isthmus and the roof plate of the anterior neural tube. At the developmental stage when the ventral dopaminergic neuron territory is being established, Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area that lies close to the ventral midline. 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We have identified by expression profiling a putative non-coding RNA, Rmst, that exhibits prominent expression in the midbrain floor plate region, the isthmus and the roof plate of the anterior neural tube. At the developmental stage when the ventral dopaminergic neuron territory is being established, Rmst expression appears to be restricted to the presumptive dopaminergic neurons of the ventral tegmental area that lies close to the ventral midline. Thus this study presents Rmst as a novel marker for the developing dopaminergic neurons in the mesencephalic floor plate as well as a marker for the dorsal midline cells of the anterior neural tube and the isthmic organizer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20062813</pmid><doi>10.1371/journal.pone.0008641</doi><tpages>e8641</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Base Sequence Biomarkers - metabolism Blotting, Northern Brain - embryology Brain - metabolism Coding Developmental Biology/Neurodevelopment DNA Primers Dopamine Dopamine receptors Floor plate Gene expression Genetics and Genomics/Gene Discovery Hybridization In Situ Hybridization Medicine Mesencephalon Mice Nervous system Neural tube Neurons Neuroscience/Neurodevelopment Non-coding RNA Phenols Ribonucleic acid RNA Spinal cord Studies Territory Ventral tegmentum |
| title | Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells |
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