Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA

Exonuclease 1 (EXO1) and Flap endonuclease 1 (FEN1) are members of the RAD2 family of structure-specific nucleases. Genetic analysis has identified roles for EXO1 and FEN1 in replication, recombination, DNA repair and maintenance of telomeres. Telomeres are composed of G-rich repeats that readily fo...

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Veröffentlicht in:	PloS one 2010-01, Vol.5 (1), p.e8908-e8908
Hauptverfasser:	Vallur, Aarthy C, Maizels, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens Base Sequence Bearing Biochemistry Biochemistry/ and Repair Class switching Deoxyribonucleic acid DNA DNA - metabolism DNA binding proteins DNA biosynthesis DNA methylation DNA Primers DNA repair DNA Replication Endonuclease Enzymes Exodeoxyribonucleases - metabolism Exonuclease FEN1 protein Flap Endonucleases - metabolism Flaps Genetic analysis Genetic research Genomes Humans Hydrolysis Immunology Intermediates Localization Mammals Molecular Biology Molecular Biology/DNA Molecular Biology/DNA Repair Nuclease Nucleases Recombination Recombination, Genetic Replication Ribosomal DNA Saccharomyces cerevisiae Substrate Specificity Substrates Telomerase Telomere Telomeres Transcription Yeast
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