Conservation and diversity of influenza A H1N1 HLA-restricted T cell epitope candidates for epitope-based vaccines

The immune-related evolution of influenza viruses is exceedingly complex and current vaccines against influenza must be reformulated for each influenza season because of the high degree of antigenic drift among circulating influenza strains. Delay in vaccine production is a serious problem in respon...

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Veröffentlicht in:	PloS one 2010-01, Vol.5 (1), p.e8754-e8754
Hauptverfasser:	Tan, Paul Thiamjoo, Heiny, A T, Miotto, Olivo, Salmon, Jerome, Marques, Ernesto T A, Lemonnier, Francois, August, J Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigenic determinants Antigenic drift Antigens Avian flu Avian influenza Avidity Computational Biology/Comparative Sequence Analysis Conservation Conserved sequence Drb1 protein Enzyme-linked immunosorbent assay Epidemics Epitopes Epitopes - chemistry Epitopes - immunology Exo-a-sialidase Hemagglutinins Histocompatibility antigen HLA Humans Immunization Immunology/Immune Response Immunology/Immunity to Infections Infectious Diseases/Viral Infections Influenza Influenza A Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - immunology Interferon Lectins Localization Lymphocytes Lymphocytes T Mice Mice, Transgenic Molecular Sequence Data Mutation Pandemics Peptides Proteins Proteomes Strains (organisms) Structural proteins Swine flu Swine influenza T cells T-Lymphocytes - immunology Transgenic mice Vaccines Viral infections Virology/Vaccines Viruses γ-Interferon
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