Community-acquired pneumonia due to pandemic A(H1N1)2009 influenzavirus and methicillin resistant Staphylococcus aureus co-infection
Bacterial pneumonia is a well described complication of influenza. In recent years, community-onset methicillin-resistant Staphylococcus aureus (cMRSA) infection has emerged as a contributor to morbidity and mortality in patients with influenza. Since the emergence and rapid dissemination of pandemi...
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| description | Bacterial pneumonia is a well described complication of influenza. In recent years, community-onset methicillin-resistant Staphylococcus aureus (cMRSA) infection has emerged as a contributor to morbidity and mortality in patients with influenza. Since the emergence and rapid dissemination of pandemic A(H1N1)2009 influenzavirus in April 2009, initial descriptions of the clinical features of patients hospitalized with pneumonia have contained few details of patients with bacterial co-infection.
Patients with community-acquired pneumonia (CAP) caused by co-infection with pandemic A(H1N1)2009 influenzavirus and cMRSA were prospectively identified at two tertiary hospitals in one Australian city during July to September 2009, the period of intense influenza activity in our region. Detailed characterization of the cMRSA isolates was performed. 252 patients with pandemic A(H1N1)2009 influenzavirus infection were admitted at the two sites during the period of study. Three cases of CAP due to pandemic A(H1N1)2009/cMRSA co-infection were identified. The clinical features of these patients were typical of those with S. aureus co-infection or sequential infection following influenza. The 3 patients received appropriate empiric therapy for influenza, but inappropriate empiric therapy for cMRSA infection; all 3 survived. In addition, 2 fatal cases of CAP caused by pandemic A(H1N1)2009/cMRSA co-infection were identified on post-mortem examination. The cMRSA infections were caused by three different cMRSA clones, only one of which contained genes for Panton-Valentine Leukocidin (PVL).
Clinicians managing patients with pandemic A(H1N1)2009 influenzavirus infection should be alert to the possibility of co-infection or sequential infection with virulent, antimicrobial-resistant bacterial pathogens such as cMRSA. PVL toxin is not necessary for the development of cMRSA pneumonia in the setting of pandemic A( H1N1) 2009 influenzavirus co-infection. |
| doi_str_mv | 10.1371/journal.pone.0008705 |
| format | Article |
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Patients with community-acquired pneumonia (CAP) caused by co-infection with pandemic A(H1N1)2009 influenzavirus and cMRSA were prospectively identified at two tertiary hospitals in one Australian city during July to September 2009, the period of intense influenza activity in our region. Detailed characterization of the cMRSA isolates was performed. 252 patients with pandemic A(H1N1)2009 influenzavirus infection were admitted at the two sites during the period of study. Three cases of CAP due to pandemic A(H1N1)2009/cMRSA co-infection were identified. The clinical features of these patients were typical of those with S. aureus co-infection or sequential infection following influenza. The 3 patients received appropriate empiric therapy for influenza, but inappropriate empiric therapy for cMRSA infection; all 3 survived. In addition, 2 fatal cases of CAP caused by pandemic A(H1N1)2009/cMRSA co-infection were identified on post-mortem examination. The cMRSA infections were caused by three different cMRSA clones, only one of which contained genes for Panton-Valentine Leukocidin (PVL).
Clinicians managing patients with pandemic A(H1N1)2009 influenzavirus infection should be alert to the possibility of co-infection or sequential infection with virulent, antimicrobial-resistant bacterial pathogens such as cMRSA. PVL toxin is not necessary for the development of cMRSA pneumonia in the setting of pandemic A( H1N1) 2009 influenzavirus co-infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0008705</identifier><identifier>PMID: 20090931</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antibiotics ; Australia - epidemiology ; Avian flu ; Bacteria ; Communities ; Community-Acquired Infections - complications ; Community-Acquired Infections - epidemiology ; Deoxyribonucleic acid ; DNA ; Drug resistance ; Forensic pathology ; Hospitals ; Humans ; Infections ; Infectious Diseases ; Infectious Diseases/Antimicrobials and Drug Resistance ; Infectious Diseases/Bacterial Infections ; Infectious Diseases/Respiratory Infections ; Infectious Diseases/Viral Infections ; Influenza ; Influenza A Virus, H1N1 Subtype - isolation & purification ; Influenza, Human - complications ; Influenza, Human - epidemiology ; Influenza, Human - virology ; Laboratories ; Leukocidin ; Medicine ; Methicillin ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Morbidity ; Mortality ; Pandemics ; Patients ; Pattern recognition ; Pneumonia ; Pneumonia, Bacterial - complications ; Pneumonia, Bacterial - epidemiology ; Polymerase chain reaction ; Staphylococcal Infections - complications ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus infections ; Therapy</subject><ispartof>PloS one, 2010-01, Vol.5 (1), p.e8705-e8705</ispartof><rights>2010 Murray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Murray et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-b01c3b58b7f493b756afc733a729e93439472ec19a857ac853c244610b8950533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806836/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806836/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20090931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murray, Ronan J</creatorcontrib><creatorcontrib>Robinson, James O</creatorcontrib><creatorcontrib>White, Jodi N</creatorcontrib><creatorcontrib>Hughes, Frank</creatorcontrib><creatorcontrib>Coombs, Geoffrey W</creatorcontrib><creatorcontrib>Pearson, Julie C</creatorcontrib><creatorcontrib>Tan, Hui-Leen</creatorcontrib><creatorcontrib>Chidlow, Glenys</creatorcontrib><creatorcontrib>Williams, Simon</creatorcontrib><creatorcontrib>Christiansen, Keryn J</creatorcontrib><creatorcontrib>Smith, David W</creatorcontrib><title>Community-acquired pneumonia due to pandemic A(H1N1)2009 influenzavirus and methicillin resistant Staphylococcus aureus co-infection</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Bacterial pneumonia is a well described complication of influenza. In recent years, community-onset methicillin-resistant Staphylococcus aureus (cMRSA) infection has emerged as a contributor to morbidity and mortality in patients with influenza. Since the emergence and rapid dissemination of pandemic A(H1N1)2009 influenzavirus in April 2009, initial descriptions of the clinical features of patients hospitalized with pneumonia have contained few details of patients with bacterial co-infection.
Patients with community-acquired pneumonia (CAP) caused by co-infection with pandemic A(H1N1)2009 influenzavirus and cMRSA were prospectively identified at two tertiary hospitals in one Australian city during July to September 2009, the period of intense influenza activity in our region. Detailed characterization of the cMRSA isolates was performed. 252 patients with pandemic A(H1N1)2009 influenzavirus infection were admitted at the two sites during the period of study. Three cases of CAP due to pandemic A(H1N1)2009/cMRSA co-infection were identified. The clinical features of these patients were typical of those with S. aureus co-infection or sequential infection following influenza. The 3 patients received appropriate empiric therapy for influenza, but inappropriate empiric therapy for cMRSA infection; all 3 survived. In addition, 2 fatal cases of CAP caused by pandemic A(H1N1)2009/cMRSA co-infection were identified on post-mortem examination. The cMRSA infections were caused by three different cMRSA clones, only one of which contained genes for Panton-Valentine Leukocidin (PVL).
Clinicians managing patients with pandemic A(H1N1)2009 influenzavirus infection should be alert to the possibility of co-infection or sequential infection with virulent, antimicrobial-resistant bacterial pathogens such as cMRSA. PVL toxin is not necessary for the development of cMRSA pneumonia in the setting of pandemic A( H1N1) 2009 influenzavirus co-infection.</description><subject>Antibiotics</subject><subject>Australia - epidemiology</subject><subject>Avian flu</subject><subject>Bacteria</subject><subject>Communities</subject><subject>Community-Acquired Infections - complications</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Forensic pathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Infectious Diseases/Antimicrobials and Drug Resistance</subject><subject>Infectious Diseases/Bacterial Infections</subject><subject>Infectious Diseases/Respiratory Infections</subject><subject>Infectious Diseases/Viral Infections</subject><subject>Influenza</subject><subject>Influenza A Virus, H1N1 Subtype - isolation & purification</subject><subject>Influenza, Human - complications</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - virology</subject><subject>Laboratories</subject><subject>Leukocidin</subject><subject>Medicine</subject><subject>Methicillin</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Pattern recognition</subject><subject>Pneumonia</subject><subject>Pneumonia, Bacterial - complications</subject><subject>Pneumonia, Bacterial - epidemiology</subject><subject>Polymerase chain reaction</subject><subject>Staphylococcal Infections - complications</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Therapy</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqFkktv1DAUhSMEou3AP0AQiQWwyOBHHNubStUIaKUKFsDachyn45Fjp35UGtb88CZMWrUIiZUt-zvH916fongFwRpiCj_ufA5O2vXonV4DABgF5ElxDDlGVYMAfvpgf1ScxLgDgGDWNM-LIwQABxzD4-L3xg9DdibtK6muswm6K0en8-CdkWWXdZl8OUrX6cGo8uz9OfwKP8zy0rjeZu1-yRsTciwnpBx02hplrDWuDDqamKRL5fckx-3eeuWVmsEc9LQoX00OWiXj3YviWS9t1C-XdVX8_Pzpx-a8uvz25WJzdlkpQmiqWgAVbglraV9z3FLSyF5RjCVFXHNcY15TpBXkkhEqFSNYobpuIGgZJ1PveFW8OfiO1kexDDAKiBhHhHA4ExcHovNyJ8ZgBhn2wksj_hz4cCVkSEZZLShnWHIOMO153feaSwhY1_B2KgMioCav0-W13A66U9qlIO0j08c3zmzFlb8RiIGG4WYyeLcYBH-ddUxiMFFpa6XTPkdBa0Lh9KXo_yTGpEZkmtqqePsX-e8x1AdKBR9j0P191RCIOX13KjGnTyzpm2SvH3Z8L7qLG74FaNbYcw</recordid><startdate>20100114</startdate><enddate>20100114</enddate><creator>Murray, Ronan J</creator><creator>Robinson, James O</creator><creator>White, Jodi N</creator><creator>Hughes, Frank</creator><creator>Coombs, Geoffrey W</creator><creator>Pearson, Julie C</creator><creator>Tan, Hui-Leen</creator><creator>Chidlow, Glenys</creator><creator>Williams, Simon</creator><creator>Christiansen, Keryn J</creator><creator>Smith, David W</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20100114</creationdate><title>Community-acquired pneumonia due to pandemic A(H1N1)2009 influenzavirus and methicillin resistant Staphylococcus aureus co-infection</title><author>Murray, Ronan J ; Robinson, James O ; White, Jodi N ; Hughes, Frank ; Coombs, Geoffrey W ; Pearson, Julie C ; Tan, Hui-Leen ; Chidlow, Glenys ; Williams, Simon ; Christiansen, Keryn J ; Smith, David W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-b01c3b58b7f493b756afc733a729e93439472ec19a857ac853c244610b8950533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antibiotics</topic><topic>Australia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murray, Ronan J</au><au>Robinson, James O</au><au>White, Jodi N</au><au>Hughes, Frank</au><au>Coombs, Geoffrey W</au><au>Pearson, Julie C</au><au>Tan, Hui-Leen</au><au>Chidlow, Glenys</au><au>Williams, Simon</au><au>Christiansen, Keryn J</au><au>Smith, David W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Community-acquired pneumonia due to pandemic A(H1N1)2009 influenzavirus and methicillin resistant Staphylococcus aureus co-infection</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2010-01-14</date><risdate>2010</risdate><volume>5</volume><issue>1</issue><spage>e8705</spage><epage>e8705</epage><pages>e8705-e8705</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Bacterial pneumonia is a well described complication of influenza. In recent years, community-onset methicillin-resistant Staphylococcus aureus (cMRSA) infection has emerged as a contributor to morbidity and mortality in patients with influenza. Since the emergence and rapid dissemination of pandemic A(H1N1)2009 influenzavirus in April 2009, initial descriptions of the clinical features of patients hospitalized with pneumonia have contained few details of patients with bacterial co-infection.
Patients with community-acquired pneumonia (CAP) caused by co-infection with pandemic A(H1N1)2009 influenzavirus and cMRSA were prospectively identified at two tertiary hospitals in one Australian city during July to September 2009, the period of intense influenza activity in our region. Detailed characterization of the cMRSA isolates was performed. 252 patients with pandemic A(H1N1)2009 influenzavirus infection were admitted at the two sites during the period of study. Three cases of CAP due to pandemic A(H1N1)2009/cMRSA co-infection were identified. The clinical features of these patients were typical of those with S. aureus co-infection or sequential infection following influenza. The 3 patients received appropriate empiric therapy for influenza, but inappropriate empiric therapy for cMRSA infection; all 3 survived. In addition, 2 fatal cases of CAP caused by pandemic A(H1N1)2009/cMRSA co-infection were identified on post-mortem examination. The cMRSA infections were caused by three different cMRSA clones, only one of which contained genes for Panton-Valentine Leukocidin (PVL).
Clinicians managing patients with pandemic A(H1N1)2009 influenzavirus infection should be alert to the possibility of co-infection or sequential infection with virulent, antimicrobial-resistant bacterial pathogens such as cMRSA. PVL toxin is not necessary for the development of cMRSA pneumonia in the setting of pandemic A( H1N1) 2009 influenzavirus co-infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>20090931</pmid><doi>10.1371/journal.pone.0008705</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1289255913 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Antibiotics Australia - epidemiology Avian flu Bacteria Communities Community-Acquired Infections - complications Community-Acquired Infections - epidemiology Deoxyribonucleic acid DNA Drug resistance Forensic pathology Hospitals Humans Infections Infectious Diseases Infectious Diseases/Antimicrobials and Drug Resistance Infectious Diseases/Bacterial Infections Infectious Diseases/Respiratory Infections Infectious Diseases/Viral Infections Influenza Influenza A Virus, H1N1 Subtype - isolation & purification Influenza, Human - complications Influenza, Human - epidemiology Influenza, Human - virology Laboratories Leukocidin Medicine Methicillin Methicillin-Resistant Staphylococcus aureus - isolation & purification Morbidity Mortality Pandemics Patients Pattern recognition Pneumonia Pneumonia, Bacterial - complications Pneumonia, Bacterial - epidemiology Polymerase chain reaction Staphylococcal Infections - complications Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus infections Therapy |
| title | Community-acquired pneumonia due to pandemic A(H1N1)2009 influenzavirus and methicillin resistant Staphylococcus aureus co-infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T13%3A49%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Community-acquired%20pneumonia%20due%20to%20pandemic%20A(H1N1)2009%20influenzavirus%20and%20methicillin%20resistant%20Staphylococcus%20aureus%20co-infection&rft.jtitle=PloS%20one&rft.au=Murray,%20Ronan%20J&rft.date=2010-01-14&rft.volume=5&rft.issue=1&rft.spage=e8705&rft.epage=e8705&rft.pages=e8705-e8705&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0008705&rft_dat=%3Cproquest_plos_%3E733542549%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1289255913&rft_id=info:pmid/20090931&rft_doaj_id=oai_doaj_org_article_7983a99037f94ffe9a108d69b394120c&rfr_iscdi=true |