Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein

Trypanosoma brucei does not respond transcriptionally to several endoplasmic reticulum (ER) stress conditions, including tunicamycin or dithiothreitol, indicating the absence of a conventional unfolded protein response. This suggests divergent mechanisms for quality control (QC) of ER protein foldin...

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Veröffentlicht in:	PloS one 2010-01, Vol.5 (1), p.e8468-e8468
Hauptverfasser:	Field, Mark C, Sergeenko, Tatiana, Wang, Ya-Nan, Böhm, Susanne, Carrington, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Animals Arabidopsis Biosynthesis Blotting, Western Cell Biology/Cell Growth and Division Cell Biology/Cellular Death and Stress Responses Cell Biology/Membranes and Sorting Cell Biology/Microbial Growth and Development Cell morphology Cytology Dithiothreitol Endoplasmic reticulum Evolutionary Biology/Morphogenesis and Cell Biology Exocytosis Fluorescent Antibody Technique, Indirect Folding Genes, Protozoan Genomes Genomics Glucose Glycoproteins Infectious Diseases/Neglected Tropical Diseases Infectious Diseases/Protozoal Infections Inhibition Kinases Lysates Membrane proteins Molecular Chaperones - physiology Open Reading Frames Pathology Pathology/Immunology Pharmacology Physiological aspects Plasmids Plasmodium falciparum Polypeptides Proteasome 26S Protein folding Protein transport Proteins Quality control Ribonucleic acid RNA RNA Interference RNA-mediated interference Rodents Stress response Transcription Transcription factors Trypanosoma Trypanosoma brucei Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - metabolism Trypanosome Tunicamycin Variant surface glycoprotein Variant Surface Glycoproteins, Trypanosoma - biosynthesis Variant Surface Glycoproteins, Trypanosoma - genetics Yeast
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