Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells

The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological similarity suggests that epigenetic processes may phenocopy the Familial Alzheimer's disease (FAD) mutations within sporadic AD. Numero...

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Veröffentlicht in:	PloS one 2010-02, Vol.5 (2), p.e9135
Hauptverfasser:	Wiley, Jesse C, Meabon, James S, Frankowski, Harald, Smith, Elise A, Schecterson, Leslayann C, Bothwell, Mark, Ladiges, Warren C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Advertising executives Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals Anti-Bacterial Agents - pharmacology Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biochemical markers Biochemistry/Drug Discovery Biophysics Blotting, Western Brain Brefeldin A Brefeldin A - pharmacology Cancer Cell Biology/Cell Signaling Cell Biology/Cellular Death and Stress Responses Cell Biology/Membranes and Sorting Cell Biology/Neuronal Signaling Mechanisms Cell Line, Tumor Cleavage Defects Dose-Response Relationship, Drug Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Epigenetic inheritance Epigenetics Genetic aspects Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunohistochemistry Ischemia Localization Mutation Neuroblastoma Neuroblastoma cells Neurodegenerative diseases Neurological Disorders Neurological Disorders/Alzheimer Disease Neurons Neurons - drug effects Neurons - metabolism Neurons - pathology Pathogenesis Pathology Pharmacology Phenylbutyrates - pharmacology Phenylbutyric acid Physiology Presenilin Prevention Protein folding Protein Transport - drug effects Proteins Proteolysis Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Secretase Signaling Stress Stresses Thapsigargin Thapsigargin - pharmacology Transfection Tunicamycin Tunicamycin - pharmacology
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