The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury

Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological functions. Recently, it was shown that Toll-like receptor 2 (TLR2) is expressed in the kidney and activated by endogenous danger signals. The...

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Veröffentlicht in:	PloS one 2009-05, Vol.4 (5), p.e5704-e5704
Hauptverfasser:	Leemans, Jaklien C, Butter, Loes M, Pulskens, Wilco P C, Teske, Gwendoline J D, Claessen, Nike, van der Poll, Tom, Florquin, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biopsy Bone marrow Cell Proliferation Chemokines Chemokines - metabolism Chromosomal proteins Disease Progression Enzyme Activation Extracellular Matrix - metabolism Fibroblasts Fibroblasts - enzymology Fibroblasts - pathology Fibrosis Gene expression Glycoprotein gp96 Hazards HMGB1 protein Humans Hypotheses Immunology/Innate Immunity Inflammation Inflammation - immunology Inflammation - pathology Injuries Kidney - enzymology Kidney - pathology Kidney diseases Kidney Diseases - enzymology Kidney Diseases - immunology Kidney Diseases - pathology Kidney transplantation Kidney Tubules - metabolism Kidney Tubules - pathology Kidneys Leukocytes (neutrophilic) Ligands Localization Male Matrix Metalloproteinases - metabolism Mice Mice, Inbred C57BL Nephrology/Chronic Kidney Disease Nephrology/Tubulointerstitial Diseases Nephropathy Pathology Pathology/Immunology Physiological aspects Renal function Rodents TLR2 protein Toll-Like Receptor 2 - deficiency Toll-Like Receptor 2 - metabolism Toll-like receptors Transforming Growth Factor beta - metabolism Transforming growth factors Up-Regulation Ureteral Obstruction - enzymology Ureteral Obstruction - pathology
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