Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients
MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this...
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| creator | Tanaka, Masami Oikawa, Kosuke Takanashi, Masakatsu Kudo, Motoshige Ohyashiki, Junko Ohyashiki, Kazuma Kuroda, Masahiko |
| description | MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this knowledge, there is little information regarding microRNAs in plasma especially because microRNAs in plasma, if exist, were thought to be digested by RNase. Recent studies, however, have revealed that microRNAs exist and escape digestion in plasma.
We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body.
The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia. |
| doi_str_mv | 10.1371/journal.pone.0005532 |
| format | Article |
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We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body.
The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0005532</identifier><identifier>PMID: 19440243</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aberration ; Acute leukemia ; Antigens ; Apoptosis ; Biomarkers ; Biotechnology ; Blood plasma ; Dendritic cells ; Deregulation ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic - genetics ; Gene Expression Regulation, Neoplastic - physiology ; Heat shock proteins ; Hematology/Acute Myeloid Leukemia ; Humans ; In Situ Hybridization ; Leukemia ; Leukemia - blood ; Leukemia - genetics ; Leukemia, Myeloid, Acute - blood ; Leukemia, Myeloid, Acute - genetics ; Lung cancer ; Male ; Mass spectrometry ; Medical research ; Melanoma ; MicroRNA ; MicroRNAs ; MicroRNAs - blood ; MicroRNAs - genetics ; miRNA ; Nucleotides ; Oligonucleotide Array Sequence Analysis ; Pathology ; Pathology/Molecular Pathology ; Patients ; Plasma ; Plasmas ; Plasmas (physics) ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Regulators ; Reverse Transcriptase Polymerase Chain Reaction ; Ribonuclease ; Ribonucleic acid ; RNA ; Scientific imaging ; Tumor suppressor genes</subject><ispartof>PloS one, 2009-05, Vol.4 (5), p.e5532-e5532</ispartof><rights>COPYRIGHT 2009 Public Library of Science</rights><rights>2009 Tanaka et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Tanaka et al. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c787t-f82fea1ccf929d36742ab6d33e16d85b3dfdcbe9de729ac0c93f1920b8250ca53</citedby><cites>FETCH-LOGICAL-c787t-f82fea1ccf929d36742ab6d33e16d85b3dfdcbe9de729ac0c93f1920b8250ca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678255/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678255/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19440243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jones, Chris</contributor><creatorcontrib>Tanaka, Masami</creatorcontrib><creatorcontrib>Oikawa, Kosuke</creatorcontrib><creatorcontrib>Takanashi, Masakatsu</creatorcontrib><creatorcontrib>Kudo, Motoshige</creatorcontrib><creatorcontrib>Ohyashiki, Junko</creatorcontrib><creatorcontrib>Ohyashiki, Kazuma</creatorcontrib><creatorcontrib>Kuroda, Masahiko</creatorcontrib><title>Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this knowledge, there is little information regarding microRNAs in plasma especially because microRNAs in plasma, if exist, were thought to be digested by RNase. Recent studies, however, have revealed that microRNAs exist and escape digestion in plasma.
We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body.
The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia.</description><subject>Aberration</subject><subject>Acute leukemia</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biotechnology</subject><subject>Blood plasma</subject><subject>Dendritic cells</subject><subject>Deregulation</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Heat shock proteins</subject><subject>Hematology/Acute Myeloid Leukemia</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Leukemia</subject><subject>Leukemia - blood</subject><subject>Leukemia - genetics</subject><subject>Leukemia, Myeloid, Acute - blood</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Medical research</subject><subject>Melanoma</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Nucleotides</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Pathology</subject><subject>Pathology/Molecular Pathology</subject><subject>Patients</subject><subject>Plasma</subject><subject>Plasmas</subject><subject>Plasmas (physics)</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Regulators</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ribonuclease</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Scientific imaging</subject><subject>Tumor suppressor genes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQDwoIPHXNp0uRFWNbbwMLCensMaZrOZDZtatKu-u1NnapTWVDykHDyO_-cS06WPUZwhUiJXuz8GDrlVr3vzApCSCnBd7JjJAjOGYbk7sH5KHsQ4y4xhDN2PztCoiggLshx9vmV_9rlwWxGpwbrO-Ab0NqrXGBgO7AdW9WB3qnYKmAjUKDzN8aBVoVrE0DjA1B6HAxwZrw2rVWgTyqmG-LD7F6jXDSP5v0k-_jm9Yfzd_nF5dv1-dlFrkteDnnDcWMU0roRWNSElQVWFasJMYjVnFakbmpdGVGbEguloRakQQLDimMKtaLkJHu61-2dj3KuSZQIc4ER5ZwnYr0naq92sg82Bf9demXlT4MPG6nCYLUzUtCCQlFAhDUvMC4EN0ShmhY1MxXSMGm9nF8bq9bUOmUalFuILm86u5UbfyMxK1PEU7ins0DwX0YTB9naqI1zqjN-jJKVmArKy3-CGLLUWIYS-Owv8PYizNRGpTxt1_gUnp4k5VlREkSZgBO1uoVKq0691emfNTbZFw7PFw6JGcy3YaPGGOX6_dX_s5efluzpAbs1yg3b6N04_dC4BIs9qIOPMZjmdy8QlNOY_KqGnMZEzmOS3J4c9vGP0zwX5AdGVAvA</recordid><startdate>20090514</startdate><enddate>20090514</enddate><creator>Tanaka, Masami</creator><creator>Oikawa, Kosuke</creator><creator>Takanashi, Masakatsu</creator><creator>Kudo, Motoshige</creator><creator>Ohyashiki, Junko</creator><creator>Ohyashiki, Kazuma</creator><creator>Kuroda, Masahiko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20090514</creationdate><title>Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients</title><author>Tanaka, Masami ; Oikawa, Kosuke ; Takanashi, Masakatsu ; Kudo, Motoshige ; Ohyashiki, Junko ; Ohyashiki, Kazuma ; Kuroda, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c787t-f82fea1ccf929d36742ab6d33e16d85b3dfdcbe9de729ac0c93f1920b8250ca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aberration</topic><topic>Acute leukemia</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Biomarkers</topic><topic>Biotechnology</topic><topic>Blood plasma</topic><topic>Dendritic cells</topic><topic>Deregulation</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Heat shock proteins</topic><topic>Hematology/Acute Myeloid Leukemia</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Leukemia</topic><topic>Leukemia - blood</topic><topic>Leukemia - genetics</topic><topic>Leukemia, Myeloid, Acute - blood</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Medical research</topic><topic>Melanoma</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Nucleotides</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Pathology</topic><topic>Pathology/Molecular Pathology</topic><topic>Patients</topic><topic>Plasma</topic><topic>Plasmas</topic><topic>Plasmas (physics)</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Masami</au><au>Oikawa, Kosuke</au><au>Takanashi, Masakatsu</au><au>Kudo, Motoshige</au><au>Ohyashiki, Junko</au><au>Ohyashiki, Kazuma</au><au>Kuroda, Masahiko</au><au>Jones, Chris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2009-05-14</date><risdate>2009</risdate><volume>4</volume><issue>5</issue><spage>e5532</spage><epage>e5532</epage><pages>e5532-e5532</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this knowledge, there is little information regarding microRNAs in plasma especially because microRNAs in plasma, if exist, were thought to be digested by RNase. Recent studies, however, have revealed that microRNAs exist and escape digestion in plasma.
We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body.
The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>19440243</pmid><doi>10.1371/journal.pone.0005532</doi><tpages>e5532</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aberration Acute leukemia Antigens Apoptosis Biomarkers Biotechnology Blood plasma Dendritic cells Deregulation Female Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Heat shock proteins Hematology/Acute Myeloid Leukemia Humans In Situ Hybridization Leukemia Leukemia - blood Leukemia - genetics Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - genetics Lung cancer Male Mass spectrometry Medical research Melanoma MicroRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Nucleotides Oligonucleotide Array Sequence Analysis Pathology Pathology/Molecular Pathology Patients Plasma Plasmas Plasmas (physics) Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Regulators Reverse Transcriptase Polymerase Chain Reaction Ribonuclease Ribonucleic acid RNA Scientific imaging Tumor suppressor genes |
| title | Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients |
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