Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components

The nucleation of microtubules requires protein complexes containing gamma-tubulin, which are present in the cytoplasm and associate with the centrosome and with the mitotic spindle. We have previously shown that these interactions require the gamma-tubulin targeting factor GCP-WD/NEDD1, which has a...

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Veröffentlicht in:	PloS one 2009-06, Vol.4 (6), p.e5976-e5976
Hauptverfasser:	Haren, Laurence, Stearns, Tim, Lüders, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Cell Biology/Cell Signaling Cell Biology/Cytoskeleton Cell Cycle Proteins - metabolism Cell Line, Tumor Centrioles - metabolism Centrosome - metabolism Centrosomes Cloning, Molecular Cytoplasm Drosophila Genomes HeLa Cells Humans Insects Localization Microscopy, Fluorescence - methods Microtubules Mitosis Models, Biological Molecular Biology Mutants Mutation Phosphorylation Polo-Like Kinase 1 Protein Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Recruitment RNA - chemistry RNA Interference Spindle Apparatus Substrates Tubulin Tubulin - metabolism
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