The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells

Lysyl oxidase (LOX), an extracellular matrix remodeling enzyme, appears to have a role in promoting breast cancer cell motility and invasiveness. In addition, increased LOX expression has been correlated with decreases in both metastases-free, and overall survival in breast cancer patients. With thi...

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Veröffentlicht in:	PloS one 2009-05, Vol.4 (5), p.e5620-e5620
Hauptverfasser:	Bondareva, Alla, Downey, Charlene M, Ayres, Fabio, Liu, Wei, Boyd, Steven K, Hallgrimsson, Benedikt, Jirik, Frank R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopropionitrile - pharmacology Animals Antineoplastic Agents - pharmacology Biochemistry Biocompatibility Bioluminescence Biomedical materials Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cancer surgery Cell adhesion & migration Cell Line, Tumor Cell Proliferation Colonization Computed tomography Endothelium Extracellular matrix Extravasation Female Heart diseases Humans Hypoxia Inhibitors Injection Invasiveness Kinases Liquid oxygen Lysyl oxidase Metastases Metastasis Mice Mice, Nude Molecular biology Morphology Motility Neoplasm Metastasis - drug therapy Neoplastic Cells, Circulating - drug effects Oncology/Breast Cancer Osteolysis Oxidase Oxidative stress Pathology/Histopathology Permeability Phosphatase Phosphorylation Photon emission Polymerase chain reaction Protein-Lysine 6-Oxidase - antagonists & inhibitors Proteins Radiology and Medical Imaging/Computer Tomography Rodents Signal transduction Tumor cells Tumors X-Ray Microtomography
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