Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model

The PSA-Cre;Pten-loxP/loxP mouse prostate cancer model displays clearly defined stages of hyperplasia and cancer. Here, the initial stages of hyperplasia development are studied. Immunohistochemical staining showed that accumulated pAkt+ hyperplastic cells overexpress luminal epithelial cell marker...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2009-05, Vol.4 (5), p.e5662-e5662
Hauptverfasser:	Korsten, Hanneke, Ziel-van der Made, Angelique, Ma, Xiaoqian, van der Kwast, Theo, Trapman, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens Animals Biomarkers - metabolism Cancer Cell proliferation Cells (biology) Deactivation Disease Models, Animal Epithelial cells Epithelial Cells - enzymology Epithelial Cells - pathology Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetics and Genomics/Disease Models Genetics and Genomics/Gene Expression Hyperplasia Immunohistochemistry Inactivation Integrases - metabolism Kinases Male Markers Mice Mice, Knockout Models, Biological Neoplasm Proteins - metabolism Neoplastic Stem Cells - enzymology Oncology/Prostate Cancer Phenotype Progenitor cells Prostate - enzymology Prostate - pathology Prostate cancer Prostate-Specific Antigen - metabolism Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology PTEN Phosphohydrolase - deficiency PTEN protein Rodents Stem cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!