Does pilocarpine-induced epilepsy in adult rats require status epilepticus?

Pilocarpine-induced seizures in rats provide a widely animal model of temporal lobe epilepsy. Some evidences reported in the literature suggest that at least 1 h of status epilepticus (SE) is required to produce subsequent chronic phase, due to the SE-related acute neuronal damage. However, recent d...

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Veröffentlicht in:	PloS one 2009-06, Vol.4 (6), p.e5759-e5759
Hauptverfasser:	Navarro Mora, Graciela, Bramanti, Placido, Osculati, Francesco, Chakir, Asmaa, Nicolato, Elena, Marzola, Pasquina, Sbarbati, Andrea, Fabene, Paolo Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Blood-brain barrier Brain - pathology Chronic illnesses Cytokines Disease Models, Animal Drug dosages EEG Electroencephalography - methods Epilepsy Epilepsy, Temporal Lobe - chemically induced Histology Human pathology Inflammation Injury analysis Latency Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Morphology Muscarinic Agonists - pharmacology Neurodegeneration Neurological Disorders/Epilepsy Neurological Disorders/Neuroimaging Neurons Neuropathology Neuroscience/Neurobiology of Disease and Regeneration Neuroscience/Neuronal and Glial Cell Biology NMR Nuclear magnetic resonance Pathology Permeability Pilocarpine Pilocarpine - chemistry Pilocarpine - pharmacology Rats Rats, Wistar Registration Rodents Seizing Seizures Seizures (Medicine) Seizures - chemically induced Status epilepticus Status Epilepticus - physiopathology Temporal lobe Variance analysis
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