Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells

A major obstacle for successful cancer treatment often is the development of drug resistance in cancer cells during chemotherapy. Therefore, there is an urgent need for novel drugs with improved efficacy against tumor cells and with less toxicity on normal cells. Artesunate (ART), a powerful anti-ma...

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Veröffentlicht in:	PloS one 2007-08, Vol.2 (8), p.e693
Hauptverfasser:	Efferth, Thomas, Giaisi, Marco, Merling, Annette, Krammer, Peter H, Li-Weber, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology Analysis Animals Anthracyclines Antibiotics, Antineoplastic - pharmacology Antimalarials - pharmacology Antineoplastic drugs Antioxidants Antitumor agents Apoptosis Apoptosis - drug effects Artemisinins - pharmacology Artesunate Biocompatibility Cancer Cancer therapies Cell death Cell Line, Tumor - drug effects Chemotherapy Chinese medicine Cysteine Cytotoxicity Deoxyribonucleic acid DNA Doxorubicin Doxorubicin - pharmacology Drug dosages Drug resistance Drug Resistance, Neoplasm - physiology Drug Screening Assays, Antitumor Drugs Free Radical Scavengers - pharmacology Humans Immunology Kaposi's sarcoma Leukemia Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Lipid peroxidation Lymphocytes Lymphocytes T Malaria Medical research Metastasis Mice Microbial drug resistance Mitochondria Molecular modelling Multidrug resistance Natural products Oncology Oxidation-Reduction Oxygen Pharmacology/Drug Development Pharmacology/Drug Resistance Plasmodium falciparum Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Sarcoma Side effects Synergism Synergistic effect T cells Toxicity Tumor cell lines Tumor cells Tumor necrosis factor-TNF Tumors Vector-borne diseases Xenografts
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