Large scale gene expression profiles of regenerating inner ear sensory epithelia

Loss of inner ear sensory hair cells (HC) is a leading cause of human hearing loss and balance disorders. Unlike mammals, many lower vertebrates can regenerate these cells. We used cross-species microarrays to examine this process in the avian inner ear. Specifically, changes in expression of over 1...

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Veröffentlicht in:	PloS one 2007-06, Vol.2 (6), p.e525-e525
Hauptverfasser:	Hawkins, R David, Bashiardes, Stavros, Powder, Kara E, Sajan, Samin A, Bhonagiri, Veena, Alvarado, David M, Speck, Judith, Warchol, Mark E, Lovett, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Analysis Animals Apoptosis Balance Biology Biomarkers - metabolism Breast cancer Cell cycle Chickens - genetics Circadian rhythm Circadian rhythms Cochlea Computational Biology/Systems Biology Developmental Biology DNA binding proteins DNA methylation DNA microarrays Ear Ears & hearing Epithelial Cells - physiology Estrogens Gene expression Gene Expression Profiling Genes Genetic aspects Genetics Genetics and Genomics/Functional Genomics Genomes Genotype & phenotype Hair Hair cells Hair Cells, Auditory, Inner - physiology Hearing loss Inner ear Insulin Insulin-like growth factor I Medicine Network analysis Oligonucleotide Array Sequence Analysis Organs Otolaryngology Polycomb group proteins Proteins Regeneration Regeneration - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Tissues Transcription (Genetics) Transcription factors Transforming growth factors Vertebrates Vestibular system Wnt protein Zinc Zinc finger proteins
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