The transcriptome of the human pathogen Trypanosoma brucei at single-nucleotide resolution

The genome of Trypanosoma brucei, the causative agent of African trypanosomiasis, was published five years ago, yet identification of all genes and their transcripts remains to be accomplished. Annotation is challenged by the organization of genes transcribed by RNA polymerase II (Pol II) into long...

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Veröffentlicht in:	PLoS pathogens 2010-09, Vol.6 (9), p.e1001090-e1001090
Hauptverfasser:	Kolev, Nikolay G, Franklin, Joseph B, Carmi, Shai, Shi, Huafang, Michaeli, Shulamit, Tschudi, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding sites (Biochemistry) DNA sequencing Enzymes Gene Expression Profiling Genetic aspects Genetic transcription Genetics Genetics and Genomics Genetics and Genomics/Gene Expression Genome, Bacterial Genomes High-Throughput Nucleotide Sequencing Humans Infectious Diseases/Neglected Tropical Diseases Leishmania major Methods Molecular Biology/Bioinformatics Molecular Sequence Data Nucleotide sequencing Parasites Physiological aspects Properties Proteins Ribonucleic acid RNA RNA Polymerase II - genetics RNA Precursors - genetics RNA, Bacterial - genetics Sequence Homology, Nucleic Acid Transcription Initiation Site Transcription, Genetic Trypanosoma brucei Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - pathogenicity Trypanosoma cruzi Trypanosomiasis, African - genetics Trypanosomiasis, African - microbiology
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