Mechanisms of TSC-mediated control of synapse assembly and axon guidance

Tuberous sclerosis complex is a dominant genetic disorder produced by mutations in either of two tumor suppressor genes, TSC1 and TSC2; it is characterized by hamartomatous tumors, and is associated with severe neurological and behavioral disturbances. Mutations in TSC1 or TSC2 deregulate a conserve...

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Veröffentlicht in:	PloS one 2007-04, Vol.2 (4), p.e375-e375
Hauptverfasser:	Knox, Sarah, Ge, Hong, Dimitroff, Brian D, Ren, Yi, Howe, Katie A, Arsham, Andrew M, Easterday, Mathew C, Neufeld, Thomas P, O'Connor, Michael B, Selleck, Scott B
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Actin Animals Assembly Axon guidance Axons Bone morphogenetic proteins Brain Cell Biology Cell Cycle Proteins - physiology Cell growth Cytoskeleton Deregulation Developmental Biology Drosophila Drosophila Proteins - physiology Genetic aspects Genetic disorders Genetics Growth factors Hereditary diseases Homology Insects Insulin Kinases Laboratories Morphogenesis Morphology Mosaics Muscle proteins Mutation Nervous system Neurological complications Neuroscience Pediatrics Photoreceptors Proteins Rapamycin Retina Saxophone music Signal Transduction Sirolimus - pharmacology Stem cells Synapses Synapses - drug effects TOR protein Transcription factors Tuberous sclerosis Tuberous Sclerosis Complex 1 Tuberous Sclerosis Complex 2 Tumor suppressor genes Tumors Visual perception Visual system
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