PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90

Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening fungal infection. To identify molecules that ab...

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Veröffentlicht in:	PLoS pathogens 2010-08, Vol.6 (8), p.e1001069-e1001069
Hauptverfasser:	LaFayette, Shantelle L, Collins, Cathy, Zaas, Aimee K, Schell, Wiley A, Betancourt-Quiroz, Marisol, Gunatilaka, A A Leslie, Perfect, John R, Cowen, Leah E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Calcineurin Calcineurin - genetics Calcineurin - metabolism Candida albicans Candida albicans - genetics Candida albicans - metabolism Drug resistance in microorganisms Drug Resistance, Fungal - genetics Fungal Proteins - genetics Fungal Proteins - metabolism Fungi Heat shock proteins HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Immunoblotting Infectious Diseases/Antimicrobials and Drug Resistance Infectious Diseases/Fungal Infections Kinases Medical research Mice Microbial Sensitivity Tests Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Mortality Physiological aspects Protein Kinase C - metabolism Protein kinases Proteins Reverse Transcriptase Polymerase Chain Reaction Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Signal Transduction - physiology
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