Chemokine binding protein M3 of murine gammaherpesvirus 68 modulates the host response to infection in a natural host

Murine γ-herpesvirus 68 (MHV-68) infection of Mus musculus-derived strains of mice is an attractive model of γ-herpesvirus infection. Surprisingly, however, ablation of expression of MHV-68 M3, a secreted protein with broad chemokine-binding properties in vitro, has no discernable effect during expe...

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Veröffentlicht in:	PLoS pathogens 2011-03, Vol.7 (3), p.e1001321-e1001321
Hauptverfasser:	Hughes, David J, Kipar, Anja, Leeming, Gail H, Bennett, Elaine, Howarth, Deborah, Cummerson, Joanne A, Papoula-Pereira, Rita, Flanagan, Brian F, Sample, Jeffery T, Stewart, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apodemus sylvaticus Bronchi - immunology Bronchi - virology Cancer Cell Line Chemokines Chemokines - genetics Chemokines - immunology Cricetinae Cytokines Development and progression Gammaherpesvirinae - physiology Genetic aspects Herpes Herpesviridae Infections - genetics Herpesviridae Infections - immunology Herpesvirus Herpesvirus diseases Immunology/Immunity to Infections Infectious Diseases/Viral Infections Life sciences Lung - immunology Lung - virology Lungs Lymphoid Tissue - immunology Lymphoid Tissue - virology Mice Microbiology/Immunity to Infections Microbiology/Innate Immunity Murinae Murine gammaherpesvirus 68 Mus musculus Pathogenesis Pathology/Immunology Physiological aspects Protein binding Proteins Respiratory tract RNA polymerase Rodents Spleen - immunology Spleen - virology Studies Viral Proteins - genetics Viral Proteins - immunology Virology/Animal Models of Infection Virology/Immune Evasion Virology/Persistence and Latency Virology/Virulence Factors and Mechanisms Virus Latency - genetics Virus Latency - immunology
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