Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies

Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function. Vertebrate A-type lamins are expressed in differentiating cells, while B-type lamins are expressed ubiquitously....

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Veröffentlicht in:	PloS one 2007-06, Vol.2 (6), p.e532-e532
Hauptverfasser:	Muñoz-Alarcón, Andrés, Pavlovic, Maja, Wismar, Jasmine, Schmitt, Bertram, Eriksson, Maria, Kylsten, Per, Dushay, Mitchell S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Aging Aging, Premature - physiopathology Analysis Animals Animals, Genetically Modified Behavior, Animal Biologi Biology C gene Caenorhabditis elegans Cell Biology Cell Biology/Gene Expression Cell Biology/Nuclear Structure and Function Cell Survival Cloning Defects Developmental Biology/Aging Developmental Biology/Cell Differentiation Drosophila Drosophila - genetics Drosophila melanogaster Evolution Evolutionary Biology Evolutionary Biology/Animal Genetics Evolutionary Biology/Nuclear Structure and Function Gene expression Gene sequencing Genes Genetic aspects Genetics and Genomics/Complex Traits Genetics and Genomics/Disease Models Genetics and Genomics/Genetics of Disease Humans Insects Intermediate filament proteins Laboratories Lamin Type A - deficiency Lamin Type A - genetics Lamins Larvae Life sciences Longevity Lymphocytes B Mammals Medicin och hälsovetenskap Molecular Biology/Molecular Evolution Mortality Muscular dystrophy Mutation Mutation - genetics NATURAL SCIENCES NATURVETENSKAP Neuromuscular Diseases - physiopathology Nutrition Phenotype Phenotypes Physiology Proteins
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