Proteolytic processing of Nlrp1b is required for inflammasome activity

Nlrp1b is a NOD-like receptor that detects the catalytic activity of anthrax lethal toxin and subsequently co-oligomerizes into a pro-caspase-1 activation platform known as an inflammasome. Nlrp1b has two domains that promote oligomerization: a NACHT domain, which is a member of the AAA+ ATPase fami...

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Veröffentlicht in:	PLoS pathogens 2012-04, Vol.8 (4), p.e1002659-e1002659
Hauptverfasser:	Frew, Bradley C, Joag, Vineet R, Mogridge, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthrax Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biology Caspase 1 - genetics Caspase 1 - metabolism Cell Line Development and progression Enzyme Activation - genetics Experiments Health aspects Inflammasomes - genetics Inflammasomes - metabolism Medicine Mice Mutation NOD-like receptors Physiological aspects Plasmids Protein Processing, Post-Translational Protein Structure, Tertiary Proteins Proteolysis Toxins Virulence (Microbiology)
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