Virion assembly factories in the nucleus of polyomavirus-infected cells

Most DNA viruses replicate in the cell nucleus, although the specific sites of virion assembly are as yet poorly defined. Electron microscopy on freeze-substituted, plastic-embedded sections of murine polyomavirus (PyV)-infected 3T3 mouse fibroblasts or mouse embryonic fibroblasts (MEFs) revealed tu...

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Veröffentlicht in:	PLoS pathogens 2012-04, Vol.8 (4), p.e1002630-e1002630
Hauptverfasser:	Erickson, Kimberly D, Bouchet-Marquis, Cedric, Heiser, Katie, Szomolanyi-Tsuda, Eva, Mishra, Rabinarayan, Lamothe, Benjamin, Hoenger, Andreas, Garcea, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biology Cell nuclei Cell Nucleus - genetics Cell Nucleus - metabolism Cell Nucleus - virology DNA damage DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA, Viral - genetics DNA, Viral - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryo, Mammalian - metabolism Embryo, Mammalian - pathology Embryo, Mammalian - virology Factories Fibroblasts - metabolism Fibroblasts - pathology Fibroblasts - virology Genomes Health aspects Infections Leukemia Mice Mice, Knockout Microscopy MRE11 Homologue Protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Physiological aspects Polyoma virus Polyomavirus - physiology Polyomavirus Infections - genetics Polyomavirus Infections - metabolism Promyelocytic Leukemia Protein Proteins Symmetry Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Virulence (Microbiology) Virus Assembly - physiology Viruses
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