Modeling of the N-glycosylated transferrin receptor suggests how transferrin binding can occur within the surface coat of Trypanosoma brucei

The transferrin receptor of bloodstream form Trypanosoma brucei is a heterodimer encoded by expression site associated genes 6 and 7. This low-abundance glycoprotein with a single glycosylphosphatidylinositol membrane anchor and eight potential N-glycosylation sites is located in the flagellar pocke...

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Veröffentlicht in:	PLoS pathogens 2012-04, Vol.8 (4), p.e1002618-e1002618
Hauptverfasser:	Mehlert, Angela, Wormald, Mark R, Ferguson, Michael A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Acetylglucosamine - metabolism Animals Biology Carbohydrates Chemistry Enzymes Experiments Glossina Glycosylation Health aspects Humans Models, Molecular Molecular weight Oligosaccharides - chemistry Oligosaccharides - metabolism Parasites Physiological aspects Protein binding Protein Structure, Quaternary Protein Structure, Tertiary Proteins Protozoan Proteins - chemistry Protozoan Proteins - metabolism Receptors, Transferrin - chemistry Receptors, Transferrin - metabolism Structure-Activity Relationship Trypanosoma brucei Trypanosoma brucei brucei - chemistry Trypanosoma brucei brucei - metabolism Virulence (Microbiology)
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