Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica

Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoebic colitis. The E. histolytica Gα subunit EhGα1 ex...

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Veröffentlicht in:	PLoS Patho 2012-11, Vol.8 (11), p.e1003040-e1003040
Hauptverfasser:	Bosch, Dustin E, Kimple, Adam J, Muller, Robin E, Giguère, Patrick M, Machius, Mischa, Willard, Francis S, Temple, Brenda R S, Siderovski, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biology CHO Cells Cricetinae Cricetulus Crystal structure Crystallography, X-Ray Cytotoxicity Entamoeba histolytica Entamoeba histolytica - enzymology Entamoeba histolytica - genetics Entamoeba histolytica - immunology Entamoebiasis - enzymology Entamoebiasis - genetics Entamoebiasis - immunology Experiments G proteins Gene Expression Regulation - immunology GTP-Binding Protein alpha Subunits - chemistry GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - immunology Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - immunology Health aspects Humans Infections Inflammatory bowel disease Jurkat Cells Kinases Pathogenesis Physiological aspects Protein binding Protein Structure, Tertiary Proteins Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - immunology Rho Guanine Nucleotide Exchange Factors Transcription, Genetic - immunology Virulence (Microbiology) Virulence Factors - biosynthesis Virulence Factors - chemistry Virulence Factors - immunology
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