RNA-dependent oligomerization of APOBEC3G is required for restriction of HIV-1

The human cytidine deaminase APOBEC3G (A3G) is a potent inhibitor of retroviruses and transposable elements and is able to deaminate cytidines to uridines in single-stranded DNA replication intermediates. A3G contains two canonical cytidine deaminase domains (CDAs), of which only the C-terminal one...

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Veröffentlicht in:	PLoS pathogens 2009-03, Vol.5 (3), p.e1000330-e1000330
Hauptverfasser:	Huthoff, Hendrik, Autore, Flavia, Gallois-Montbrun, Sarah, Fraternali, Franca, Malim, Michael H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Amino Acid Sequence Amino Acid Substitution Amino acids Aminotransferases APOBEC Deaminases APOBEC-3G Deaminase Biochemistry/Protein Folding CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell Line Cytidine Deaminase - chemistry Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Escherichia coli Genetic aspects HIV infection HIV-1 - physiology Human immunodeficiency virus 1 Humans Models, Molecular Molecular Sequence Data Muscle Proteins - chemistry Muscle Proteins - genetics Mutation Physiological aspects Protein Multimerization Protein Structure, Tertiary Proteins Retrovirus RNA - metabolism Structural Homology, Protein Two-Hybrid System Techniques Virology/Host Antiviral Responses Virology/Immunodeficiency Viruses Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics Virus Assembly Virus Replication - physiology
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