Global functional analyses of cellular responses to pore-forming toxins

Here we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein toxins and being important for the pathogenesis in humans of many Gram positive...

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Veröffentlicht in:	PLoS pathogens 2011-03, Vol.7 (3), p.e1001314
Hauptverfasser:	Kao, Cheng-Yuan, Los, Ferdinand C O, Huffman, Danielle L, Wachi, Shinichiro, Kloft, Nicole, Husmann, Matthias, Karabrahimi, Valbona, Schwartz, Jean-Louis, Bellier, Audrey, Ha, Christine, Sagong, Youn, Fan, Hui, Ghosh, Partho, Hsieh, Mindy, Hsu, Chih-Shen, Chen, Li, Aroian, Raffi V
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Animals Bacteria Bacterial proteins Bacterial Proteins - toxicity Bacterial toxins Bacterial Toxins - toxicity c-Jun amino-terminal kinase c-Jun protein Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - immunology Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell interactions Cell Line Cell Membrane - metabolism Cellular signal transduction DNA microarrays Escherichia coli - metabolism Escherichia coli - pathogenicity Experiments Genes, Helminth Genetic aspects Genetics Genetics and Genomics Genetics and Genomics/Functional Genomics Genome, Helminth Genomes genomics Gram-negative bacteria Host-bacteria relationships Humans Hypersensitivity Immunology Immunology/Innate Immunity Infectious Diseases Infectious Diseases/Bacterial Infections Kinases MAP kinase MAP Kinase Signaling System Microbiology Oligonucleotide Array Sequence Analysis Pathogenesis Physiological aspects Plasma Plasma membranes Polymerase chain reaction Pore Forming Cytotoxic Proteins - toxicity Pore size Pores Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Helminth - genetics RNA, Messenger - metabolism RNA-mediated interference Signal Transduction Streptococcus infections Toxins Transcription Transcription Factor AP-1 - metabolism Transcription factors Transcription, Genetic Virulence (Microbiology) virulence factors Virulence Factors - metabolism
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