Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors

Botulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic vesicle protein SV2 as the protein receptor for BoNT/D. BoNT/D enters cultured hippoc...

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Veröffentlicht in:	PLoS pathogens 2011-03, Vol.7 (3), p.e1002008
Hauptverfasser:	Peng, Lisheng, Tepp, William H, Johnson, Eric A, Dong, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Botulinum toxin Botulinum Toxins - metabolism Botulinum Toxins, Type A - metabolism Cell Line Cell Membrane - metabolism Gangliosides Gangliosides - metabolism Genetic aspects HEK293 Cells Humans Medicine Membrane Glycoproteins - metabolism Mice Nerve Tissue Proteins - metabolism Neurons Physiological aspects Plasma Protein Binding Protein Isoforms - metabolism Proteins Synaptic Vesicles - metabolism Toxins
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