Myeloid infection links epithelial and B cell tropisms of murid herpesvirus-4

Gamma-herpesviruses persist in lymphocytes and cause disease by driving their proliferation. Lymphocyte infection is therefore a key pathogenetic event. Murid Herpesvirus-4 (MuHV-4) is a rhadinovirus that like the related Kaposi's Sarcoma-associated Herpesvirus persists in B cells in vivo yet i...

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Veröffentlicht in:	PLoS pathogens 2012-09, Vol.8 (9), p.e1002935-e1002935
Hauptverfasser:	Frederico, Bruno, Milho, Ricardo, May, Janet S, Gillet, Laurent, Stevenson, Philip G
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals B cells B-Lymphocytes - virology Biology CD11c Antigen Cell Line Cricetinae Deoxyribonucleic acid DNA Epithelial cells Epithelial Cells - virology Experiments Fibroblasts - virology Flow cytometry Health aspects HEK293 Cells Heparan sulfate Herpesviridae Infections - immunology Herpesviridae Infections - virology Herpesviruses Humans Immunology Life sciences Lymphocytes Macrophages - virology Mice Mice, Inbred C57BL Microbiologie Microbiology Myeloid Cells - virology Physiological aspects Proteins Rhadinovirus - immunology Rhadinovirus - pathogenicity Rhadinovirus - physiology Sciences du vivant Tumor Virus Infections - immunology Tumor Virus Infections - virology Viral Envelope Proteins - metabolism Virulence (Microbiology) Virus Internalization
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