Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei

Trypanosoma brucei is a master of antigenic variation and immune response evasion. Utilizing a genomic repertoire of more than 1000 Variant Surface Glycoprotein-encoding genes (VSGs), T. brucei can change its protein coat by "switching" from the expression of one VSG to another. Each activ...

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Veröffentlicht in:	PLoS pathogens 2012-08, Vol.8 (8), p.e1002900
Hauptverfasser:	Hovel-Miner, Galadriel A, Boothroyd, Catharine E, Mugnier, Monica, Dreesen, Oliver, Cross, George A M, Papavasiliou, F Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigenic Variation - genetics Biology Cloning DNA, Protozoan - genetics Gene Conversion Gene Duplication Genes Genetic aspects Genetic Variation Genomes Genotype & phenotype Health aspects Humans Hypotheses Microbial genetics Parasites Phenotype Physiological aspects Population Proteins Telomerase Telomerase - genetics Telomerase - metabolism Telomere - genetics Telomere - metabolism Telomere Homeostasis - genetics Telomeres Trypanosoma brucei Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - immunology Trypanosoma brucei brucei - metabolism Variant Surface Glycoproteins, Trypanosoma - genetics Variant Surface Glycoproteins, Trypanosoma - immunology Variant Surface Glycoproteins, Trypanosoma - metabolism Virulence (Microbiology)
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