Highly efficient prion transmission by blood transfusion

It is now clearly established that the transfusion of blood from variant CJD (v-CJD) infected individuals can transmit the disease. Since the number of asymptomatic infected donors remains unresolved, inter-individual v-CJD transmission through blood and blood derived products is a major public heal...

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Veröffentlicht in:	PLoS pathogens 2012-06, Vol.8 (6), p.e1002782-e1002782
Hauptverfasser:	Andréoletti, Olivier, Litaise, Claire, Simmons, Hugh, Corbière, Fabien, Lugan, Séverine, Costes, Pierrette, Schelcher, François, Vilette, Didier, Grassi, Jacques, Lacroux, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood products Blood transfusion Blood transfusions Blotting, Western Cell Survival Creutzfeldt-Jakob disease Disease Models, Animal Disease transmission Efficiency Experiments Health aspects Immunization Immunohistochemistry Leukocyte Transfusion - adverse effects Leukocytes Life Sciences Medicine Mice Mice, Transgenic Pathogenesis Physiological aspects Plasma Prion Diseases - blood Prion Diseases - transmission Prions PrPSc Proteins - blood Rodents Sheep Spongiform encephalopathies
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