The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response

The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host cell that manipulate the immune response allowing it to establish a chronic infection. Crosses between the types I, II and III strains, which are prevalent in North America and Europe, have identified seve...

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Veröffentlicht in:	PLoS pathogens 2012-06, Vol.8 (6), p.e1002784-e1002784
Hauptverfasser:	Niedelman, Wendy, Gold, Daniel A, Rosowski, Emily E, Sprokholt, Joris K, Lim, Daniel, Farid Arenas, Ailan, Melo, Mariane B, Spooner, Eric, Yaffe, Michael B, Saeij, Jeroen P J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Blotting, Western Chromatography, High Pressure Liquid Fluorescent Antibody Technique GTP Phosphohydrolases Health aspects High-Throughput Screening Assays host-resistance human-fibroblasts Humans ifn-gamma Immune Evasion - immunology Immunoprecipitation infection Interferon Interferon-gamma - immunology Kinases Mass Spectrometry Medical research Mice parasite Parasites parasitophorous vacuole Physiological aspects population-structure Protein-Serine-Threonine Kinases - immunology Proteins Reverse Transcriptase Polymerase Chain Reaction Species Specificity surface-antigen Toxoplasma Toxoplasma - immunology Toxoplasma - pathogenicity Toxoplasmosis - immunology virulence Virulence (Microbiology) Virulence - immunology
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