The role of animal models for research on severe malaria
Severe malaria shows both clinical heterogeneity between patients and the patterns of pathophysiology observed between adults and children. [...]it is important when dealing with studies on severe malaria that a reliable and consistent definition of disease is used. Relevant animal models are highly...
Gespeichert in:
| Veröffentlicht in: | PLoS pathogens 2012-02, Vol.8 (2), p.e1002401-e1002401 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e1002401 |
|---|---|
| container_issue | 2 |
| container_start_page | e1002401 |
| container_title | PLoS pathogens |
| container_volume | 8 |
| creator | Craig, Alister G Grau, Georges E Janse, Chris Kazura, James W Milner, Dan Barnwell, John W Turner, Gareth Langhorne, Jean |
| description | Severe malaria shows both clinical heterogeneity between patients and the patterns of pathophysiology observed between adults and children. [...]it is important when dealing with studies on severe malaria that a reliable and consistent definition of disease is used. Relevant animal models are highly desirable, as studies of humans with severe malaria are by definition limited to situations where clinical interventions are the priority. [...]interpretations of the result of therapies preventing CM must be done in the context of anti-malarial drug treatment and other supportive measures. (iv) Facilities to support research on severe malaria One of the major outcomes of the workshop was the requirement for further development of facilities for research. |
| doi_str_mv | 10.1371/journal.ppat.1002401 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1289097645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A282068742</galeid><doaj_id>oai_doaj_org_article_6a2a24951ef342d79c5ec16dd4904fb0</doaj_id><sourcerecordid>A282068742</sourcerecordid><originalsourceid>FETCH-LOGICAL-c619t-e27031b009e737fda499f8890d2415198e4fc43bfbe0990a5a250a05b92ee50c3</originalsourceid><addsrcrecordid>eNptkl9rFDEUxQdRbK1-A9GBPvi025t_M8mLUErVQsGX9jncydzszpKdrMlswW9v1p2WVnxKSM793XPgVNVHBksmWnaxifs0YljudjgtGQCXwF5Vp0wpsWhFK18_u59U73LeAEgmWPO2OuFcMCOFPq303ZrqFAPV0dc4DlsM9Tb2FHLtY6oTZcLk1nUc60wPlKguCkwDvq_eeAyZPsznWXX_7fru6sfi9uf3m6vL24VrmJkWxFsQrAMwVIz4HqUxXmsDPZdMMaNJeidF5zsCYwAVcgUIqjOcSIETZ9XnI3cXYrZz6GwZLwzTNlIVxc1R0Ufc2F0qGdJvG3Gwfx9iWllM0-AC2QY5cmkUIy8k71vjFDnW9L00IH0HhfV13rbvttQ7GqeE4QX05c84rO0qPljBWwaqKYAvMyDFX3vKk90O2VEIOFLcZ2u4Fo026mD7_B_l_8PNqhUW_8PoY1nrDkx7yTWHRreSF5U8qlyKOSfyT44Z2ENbHtn20BY7t6WMfXqe9mnosR7iDzbZurs</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1289097645</pqid></control><display><type>article</type><title>The role of animal models for research on severe malaria</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Craig, Alister G ; Grau, Georges E ; Janse, Chris ; Kazura, James W ; Milner, Dan ; Barnwell, John W ; Turner, Gareth ; Langhorne, Jean</creator><creatorcontrib>Craig, Alister G ; Grau, Georges E ; Janse, Chris ; Kazura, James W ; Milner, Dan ; Barnwell, John W ; Turner, Gareth ; Langhorne, Jean ; participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria ; on behalf of the participants of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria”</creatorcontrib><description>Severe malaria shows both clinical heterogeneity between patients and the patterns of pathophysiology observed between adults and children. [...]it is important when dealing with studies on severe malaria that a reliable and consistent definition of disease is used. Relevant animal models are highly desirable, as studies of humans with severe malaria are by definition limited to situations where clinical interventions are the priority. [...]interpretations of the result of therapies preventing CM must be done in the context of anti-malarial drug treatment and other supportive measures. (iv) Facilities to support research on severe malaria One of the major outcomes of the workshop was the requirement for further development of facilities for research.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1002401</identifier><identifier>PMID: 22319438</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animal diseases ; Animal models ; Animals ; Biology ; Care and treatment ; Congresses as Topic ; Disease Models, Animal ; Erythrocytes - parasitology ; Health aspects ; Heterogeneity ; Humans ; Malaria ; Malaria, Cerebral - parasitology ; Malaria, Cerebral - pathology ; Medicine ; Mice ; Opinion ; Pathology ; Physiological aspects ; Physiology, Pathological ; Plasmodium ; Plasmodium berghei - pathogenicity ; Plasmodium falciparum - pathogenicity ; Plasmodium knowlesi - pathogenicity ; Plasmodium vivax - pathogenicity ; Primates ; Rodents ; Studies ; Vector-borne diseases</subject><ispartof>PLoS pathogens, 2012-02, Vol.8 (2), p.e1002401-e1002401</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Craig et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Craig AG, Grau GE, Janse C, Kazura JW, Milner D, et al. (2012) The Role of Animal Models for Research on Severe Malaria. PLoS Pathog 8(2): e1002401. doi:10.1371/journal.ppat.1002401</rights><rights>Craig et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-e27031b009e737fda499f8890d2415198e4fc43bfbe0990a5a250a05b92ee50c3</citedby><cites>FETCH-LOGICAL-c619t-e27031b009e737fda499f8890d2415198e4fc43bfbe0990a5a250a05b92ee50c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271056/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271056/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22319438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Craig, Alister G</creatorcontrib><creatorcontrib>Grau, Georges E</creatorcontrib><creatorcontrib>Janse, Chris</creatorcontrib><creatorcontrib>Kazura, James W</creatorcontrib><creatorcontrib>Milner, Dan</creatorcontrib><creatorcontrib>Barnwell, John W</creatorcontrib><creatorcontrib>Turner, Gareth</creatorcontrib><creatorcontrib>Langhorne, Jean</creatorcontrib><creatorcontrib>participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria</creatorcontrib><creatorcontrib>on behalf of the participants of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria”</creatorcontrib><title>The role of animal models for research on severe malaria</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>Severe malaria shows both clinical heterogeneity between patients and the patterns of pathophysiology observed between adults and children. [...]it is important when dealing with studies on severe malaria that a reliable and consistent definition of disease is used. Relevant animal models are highly desirable, as studies of humans with severe malaria are by definition limited to situations where clinical interventions are the priority. [...]interpretations of the result of therapies preventing CM must be done in the context of anti-malarial drug treatment and other supportive measures. (iv) Facilities to support research on severe malaria One of the major outcomes of the workshop was the requirement for further development of facilities for research.</description><subject>Animal diseases</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biology</subject><subject>Care and treatment</subject><subject>Congresses as Topic</subject><subject>Disease Models, Animal</subject><subject>Erythrocytes - parasitology</subject><subject>Health aspects</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Malaria</subject><subject>Malaria, Cerebral - parasitology</subject><subject>Malaria, Cerebral - pathology</subject><subject>Medicine</subject><subject>Mice</subject><subject>Opinion</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Physiology, Pathological</subject><subject>Plasmodium</subject><subject>Plasmodium berghei - pathogenicity</subject><subject>Plasmodium falciparum - pathogenicity</subject><subject>Plasmodium knowlesi - pathogenicity</subject><subject>Plasmodium vivax - pathogenicity</subject><subject>Primates</subject><subject>Rodents</subject><subject>Studies</subject><subject>Vector-borne diseases</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkl9rFDEUxQdRbK1-A9GBPvi025t_M8mLUErVQsGX9jncydzszpKdrMlswW9v1p2WVnxKSM793XPgVNVHBksmWnaxifs0YljudjgtGQCXwF5Vp0wpsWhFK18_u59U73LeAEgmWPO2OuFcMCOFPq303ZrqFAPV0dc4DlsM9Tb2FHLtY6oTZcLk1nUc60wPlKguCkwDvq_eeAyZPsznWXX_7fru6sfi9uf3m6vL24VrmJkWxFsQrAMwVIz4HqUxXmsDPZdMMaNJeidF5zsCYwAVcgUIqjOcSIETZ9XnI3cXYrZz6GwZLwzTNlIVxc1R0Ufc2F0qGdJvG3Gwfx9iWllM0-AC2QY5cmkUIy8k71vjFDnW9L00IH0HhfV13rbvttQ7GqeE4QX05c84rO0qPljBWwaqKYAvMyDFX3vKk90O2VEIOFLcZ2u4Fo026mD7_B_l_8PNqhUW_8PoY1nrDkx7yTWHRreSF5U8qlyKOSfyT44Z2ENbHtn20BY7t6WMfXqe9mnosR7iDzbZurs</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Craig, Alister G</creator><creator>Grau, Georges E</creator><creator>Janse, Chris</creator><creator>Kazura, James W</creator><creator>Milner, Dan</creator><creator>Barnwell, John W</creator><creator>Turner, Gareth</creator><creator>Langhorne, Jean</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120201</creationdate><title>The role of animal models for research on severe malaria</title><author>Craig, Alister G ; Grau, Georges E ; Janse, Chris ; Kazura, James W ; Milner, Dan ; Barnwell, John W ; Turner, Gareth ; Langhorne, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-e27031b009e737fda499f8890d2415198e4fc43bfbe0990a5a250a05b92ee50c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal diseases</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biology</topic><topic>Care and treatment</topic><topic>Congresses as Topic</topic><topic>Disease Models, Animal</topic><topic>Erythrocytes - parasitology</topic><topic>Health aspects</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Malaria</topic><topic>Malaria, Cerebral - parasitology</topic><topic>Malaria, Cerebral - pathology</topic><topic>Medicine</topic><topic>Mice</topic><topic>Opinion</topic><topic>Pathology</topic><topic>Physiological aspects</topic><topic>Physiology, Pathological</topic><topic>Plasmodium</topic><topic>Plasmodium berghei - pathogenicity</topic><topic>Plasmodium falciparum - pathogenicity</topic><topic>Plasmodium knowlesi - pathogenicity</topic><topic>Plasmodium vivax - pathogenicity</topic><topic>Primates</topic><topic>Rodents</topic><topic>Studies</topic><topic>Vector-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craig, Alister G</creatorcontrib><creatorcontrib>Grau, Georges E</creatorcontrib><creatorcontrib>Janse, Chris</creatorcontrib><creatorcontrib>Kazura, James W</creatorcontrib><creatorcontrib>Milner, Dan</creatorcontrib><creatorcontrib>Barnwell, John W</creatorcontrib><creatorcontrib>Turner, Gareth</creatorcontrib><creatorcontrib>Langhorne, Jean</creatorcontrib><creatorcontrib>participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria</creatorcontrib><creatorcontrib>on behalf of the participants of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria”</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craig, Alister G</au><au>Grau, Georges E</au><au>Janse, Chris</au><au>Kazura, James W</au><au>Milner, Dan</au><au>Barnwell, John W</au><au>Turner, Gareth</au><au>Langhorne, Jean</au><aucorp>participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria</aucorp><aucorp>on behalf of the participants of the Hinxton Retreat meeting on “Animal Models for Research on Severe Malaria”</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of animal models for research on severe malaria</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>8</volume><issue>2</issue><spage>e1002401</spage><epage>e1002401</epage><pages>e1002401-e1002401</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>Severe malaria shows both clinical heterogeneity between patients and the patterns of pathophysiology observed between adults and children. [...]it is important when dealing with studies on severe malaria that a reliable and consistent definition of disease is used. Relevant animal models are highly desirable, as studies of humans with severe malaria are by definition limited to situations where clinical interventions are the priority. [...]interpretations of the result of therapies preventing CM must be done in the context of anti-malarial drug treatment and other supportive measures. (iv) Facilities to support research on severe malaria One of the major outcomes of the workshop was the requirement for further development of facilities for research.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22319438</pmid><doi>10.1371/journal.ppat.1002401</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1553-7374 |
| ispartof | PLoS pathogens, 2012-02, Vol.8 (2), p.e1002401-e1002401 |
| issn | 1553-7374 1553-7366 1553-7374 |
| language | eng |
| recordid | cdi_plos_journals_1289097645 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Animal diseases Animal models Animals Biology Care and treatment Congresses as Topic Disease Models, Animal Erythrocytes - parasitology Health aspects Heterogeneity Humans Malaria Malaria, Cerebral - parasitology Malaria, Cerebral - pathology Medicine Mice Opinion Pathology Physiological aspects Physiology, Pathological Plasmodium Plasmodium berghei - pathogenicity Plasmodium falciparum - pathogenicity Plasmodium knowlesi - pathogenicity Plasmodium vivax - pathogenicity Primates Rodents Studies Vector-borne diseases |
| title | The role of animal models for research on severe malaria |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A40%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20animal%20models%20for%20research%20on%20severe%20malaria&rft.jtitle=PLoS%20pathogens&rft.au=Craig,%20Alister%20G&rft.aucorp=participants%20of%20the%20Hinxton%20Retreat%20meeting%20on%20Animal%20Models%20for%20Research%20on%20Severe%20Malaria&rft.date=2012-02-01&rft.volume=8&rft.issue=2&rft.spage=e1002401&rft.epage=e1002401&rft.pages=e1002401-e1002401&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.1002401&rft_dat=%3Cgale_plos_%3EA282068742%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1289097645&rft_id=info:pmid/22319438&rft_galeid=A282068742&rft_doaj_id=oai_doaj_org_article_6a2a24951ef342d79c5ec16dd4904fb0&rfr_iscdi=true |