KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif

Molecular interactions between killer immunoglobulin-like receptors (KIRs) and their MHC class I ligands play a central role in the regulation of natural killer (NK) cell responses to viral pathogens and tumors. Here we identify Mamu-A1*00201 (Mamu-A*02), a common MHC class I molecule in the rhesus...

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Veröffentlicht in:	PLoS pathogens 2011-03, Vol.7 (3), p.e1001316
Hauptverfasser:	Colantonio, Arnaud D, Bimber, Benjamin N, Neidermyer, Jr, William J, Reeves, R Keith, Alter, Galit, Altfeld, Marcus, Johnson, R Paul, Carrington, Mary, O'Connor, David H, Evans, David T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell receptors Cloning Cloning, Molecular Epitopes, T-Lymphocyte - metabolism Flow cytometry Genetic aspects Genetic polymorphisms Histocompatibility Antigens Class I - metabolism HLA-B Antigens - genetics Host-Pathogen Interactions Humans Immune response Immune system Immunology Immunology/Immune Response Immunology/Innate Immunity Infectious Diseases/HIV Infection and AIDS Infectious Diseases/Viral Infections Jurkat Cells Killer cells Ligands Macaca mulatta Microbiology/Innate Immunity Peptides Peptides - metabolism Physiological aspects Polymorphism, Single Nucleotide Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Protein Binding Protein Conformation Proteins Simian Acquired Immunodeficiency Syndrome - genetics Simian Acquired Immunodeficiency Syndrome - metabolism Simian Acquired Immunodeficiency Syndrome - virology T cell receptors T-Lymphocytes - metabolism Transfection Virology/Animal Models of Infection Virology/Immune Evasion Virology/Immunodeficiency Viruses Women
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