Ifitm3 limits the severity of acute influenza in mice

Interferon-induced transmembrane (IFITM) proteins are a family of viral restriction factors that inhibit the entry processes of several pathogenic viruses, including influenza A virus (IAV), in vitro. Here we report that IAV-infected knockout mice lacking the Ifitm locus on chromosome 7 exhibited ac...

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Veröffentlicht in:	PLoS pathogens 2012-09, Vol.8 (9), p.e1002909-e1002909
Hauptverfasser:	Bailey, Charles C, Huang, I-Chueh, Kam, Christina, Farzan, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acute Disease Alveoli Animals Biology Cell culture Cells, Cultured Chick Embryo chromosome 7 Chromosomes Cytokines Disease Resistance - genetics Epithelial cells Experiments Genetic aspects Genetic engineering Genetic Predisposition to Disease - genetics Genomes Glycoprotein gp130 Health aspects Humans Infection Influenza Influenza A Influenza A virus Influenza A virus - pathogenicity Influenza viruses Interferon Interleukin 6 Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Microscopy Mortality NIH 3T3 Cells oncostatin M Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - prevention & control Pathogens Physiological aspects pneumocytes Promoters Proteins Severity of Illness Index Viral genetics Viral infections Virulence (Microbiology) Viruses
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