The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding

Capnocytophaga canimorsus is a usual member of dog's mouths flora that causes rare but dramatic human infections after dog bites. We determined the structure of C. canimorsus lipid A. The main features are that it is penta-acylated and composed of a "hybrid backbone" lacking the 4...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PLoS pathogens 2012-05, Vol.8 (5), p.e1002667-e1002667
Hauptverfasser:	Ittig, Simon, Lindner, Buko, Stenta, Marco, Manfredi, Pablo, Zdorovenko, Evelina, Knirel, Yuriy A, dal Peraro, Matteo, Cornelis, Guy R, Zähringer, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - metabolism Animals Antigens, CD - metabolism Bacillus (Bacteria) Binding sites Biology Capnocytophaga - metabolism Capnocytophaga - pathogenicity Carrier Proteins - metabolism Cell Line Dogs E coli Endotoxins - chemistry Endotoxins - metabolism Experiments Fatty acids Health aspects HEK293 Cells Humans Immune system Interleukin-6 - secretion Lipid A - chemistry Lipid A - metabolism Lipids Lipopolysaccharide Receptors - metabolism Lipopolysaccharides Macrophages - metabolism Membrane Glycoproteins - metabolism Models, Molecular Physiological aspects Protein binding Protein Structure, Tertiary Sugar Acids - metabolism Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - secretion Virulence (Microbiology)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!