Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1

Several viruses encode factors that promote host mRNA degradation to silence gene expression. It is unclear, however, whether cellular mRNA turnover pathways are engaged to assist in this process. In Kaposi's sarcoma-associated herpesvirus this phenotype is enacted by the host shutoff factor SO...

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Veröffentlicht in:	PLoS pathogens 2011-10, Vol.7 (10), p.e1002339-e1002339
Hauptverfasser:	Covarrubias, Sergio, Gaglia, Marta M, Kumar, G Renuka, Wong, Wesley, Jackson, Andrew O, Glaunsinger, Britt A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology Cloning Enzymes Exonucleases Exoribonucleases - genetics Exoribonucleases - metabolism Experiments Gene expression Gene Expression Regulation, Viral Genetic translation Health aspects Herpesvirus 8, Human - genetics Herpesvirus 8, Human - metabolism Herpesvirus 8, Human - pathogenicity Herpesviruses HLA-DR Antigens - genetics HLA-DR Antigens - metabolism Host-Pathogen Interactions Humans Kaposis sarcoma Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Physiological aspects Proteins Ribonucleases - genetics Ribonucleases - metabolism RNA, Messenger - metabolism SOX Transcription Factors - genetics Viral Proteins - genetics Viral Proteins - metabolism Virion - genetics Virion - metabolism Viruses
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