An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export
The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of addit...
Gespeichert in:
Veröffentlicht in: | PLoS pathogens 2011-07, Vol.7 (7), p.e1002138-e1002138 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | e1002138 |
---|---|
container_issue | 7 |
container_start_page | e1002138 |
container_title | PLoS pathogens |
container_volume | 7 |
creator | Jackson, Brian R Boyne, James R Noerenberg, Marko Taylor, Adam Hautbergue, Guillaume M Walsh, Matthew J Wheat, Rachel Blackbourn, David J Wilson, Stuart A Whitehouse, Adrian |
description | The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently export Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs from the nucleus, the KSHV ORF57 protein recruits hTREX onto viral intronless mRNAs allowing access to the TAP-mediated export pathway. Similarly however, depletion of Aly only leads to a modest reduction in the nuclear export of KSHV intronless mRNAs. Herein, we identify a novel interaction between ORF57 and the cellular protein, UIF. We provide the first evidence that the ORF57-UIF interaction enables the recruitment of hTREX and TAP to KSHV intronless mRNAs in Aly-depleted cells. Strikingly, depletion of both Aly and UIF inhibits the formation of an ORF57-mediated nuclear export competent ribonucleoprotein particle and consequently prevents ORF57-mediated mRNA nuclear export and KSHV protein production. Importantly, these findings highlight that redundancy exists in the eukaryotic system for certain hTREX components involved in the mRNA nuclear export of intronless KSHV mRNAs. |
doi_str_mv | 10.1371/journal.ppat.1002138 |
format | Article |
fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1289087701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A263659790</galeid><doaj_id>oai_doaj_org_article_df7aad35cc464e7fad144adaa0311cf6</doaj_id><sourcerecordid>A263659790</sourcerecordid><originalsourceid>FETCH-LOGICAL-c660t-cf0aefd32f800cb639bf5bd06f40afb5ef57981854770a7bbf64efb3991d18903</originalsourceid><addsrcrecordid>eNqVklFv0zAUhSMEYmPwDxBE4gHx0OIbJ3HyglRNlFVMm9QxXi3Hvu48pXZmJ2X797hrNq1oL8gPtuzvnOt7dJPkPZApUAZfr93grWinXSf6KRCSAa1eJIdQFHTCKMtfPjkfJG9CuCYkBwrl6-QggwryArLDpJvZ1NgevZC9cTZtsP-DaNOfFye_0_PlvGCpsCq9XMzTzruNURjS9fJsNhFKdL3zqUc1WCWsvIs-6RX6DsPG-CFsbb2zLYadIsXbzvn-bfJKizbgu3E_Si7n338dn0xOz38sjmenE1mWpJ9ITQRqRTNdESKbktaNLhpFSp0ToZsCdcHqCqoiZ4wI1jS6zFE3tK5BQVUTepR83Pl2rQt8DCtwyOJjFTUQicWOUE5c886btfB33AnD7y-cX3HheyNb5EozIRQtpMxjGaaFgjyPCQhCAaQuo9e3sdrQrFFJjL2Lds90_8WaK75yG04hB0KraPB5NPDuZsDQ87UJEttWWHRD4FUFpKozxiL56R_y-eZGaiXi_43VLpaVW08-y0paFjW7D2n6DBWXwrWRzqI28X5P8GVPEJkeb_uVGELgi4vlf7Bn-2y-Y6V3IXjUj9EB4dtxf2iSb8edj-MeZR-exv4oephv-hexxPv3</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1289087701</pqid></control><display><type>article</type><title>An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Jackson, Brian R ; Boyne, James R ; Noerenberg, Marko ; Taylor, Adam ; Hautbergue, Guillaume M ; Walsh, Matthew J ; Wheat, Rachel ; Blackbourn, David J ; Wilson, Stuart A ; Whitehouse, Adrian</creator><contributor>Glaunsinger, Britt A.</contributor><creatorcontrib>Jackson, Brian R ; Boyne, James R ; Noerenberg, Marko ; Taylor, Adam ; Hautbergue, Guillaume M ; Walsh, Matthew J ; Wheat, Rachel ; Blackbourn, David J ; Wilson, Stuart A ; Whitehouse, Adrian ; Glaunsinger, Britt A.</creatorcontrib><description>The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently export Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs from the nucleus, the KSHV ORF57 protein recruits hTREX onto viral intronless mRNAs allowing access to the TAP-mediated export pathway. Similarly however, depletion of Aly only leads to a modest reduction in the nuclear export of KSHV intronless mRNAs. Herein, we identify a novel interaction between ORF57 and the cellular protein, UIF. We provide the first evidence that the ORF57-UIF interaction enables the recruitment of hTREX and TAP to KSHV intronless mRNAs in Aly-depleted cells. Strikingly, depletion of both Aly and UIF inhibits the formation of an ORF57-mediated nuclear export competent ribonucleoprotein particle and consequently prevents ORF57-mediated mRNA nuclear export and KSHV protein production. Importantly, these findings highlight that redundancy exists in the eukaryotic system for certain hTREX components involved in the mRNA nuclear export of intronless KSHV mRNAs.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1002138</identifier><identifier>PMID: 21814512</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Active Transport, Cell Nucleus - genetics ; Biology ; Cell Nucleus - genetics ; Cell Nucleus - metabolism ; Cell Nucleus - virology ; Colleges & universities ; Competition ; Experiments ; Gene expression ; Genetic aspects ; Genetics ; HEK293 Cells ; Herpesvirus 8, Human - genetics ; Herpesvirus 8, Human - metabolism ; Herpesviruses ; Humans ; Messenger RNA ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Properties ; Proteins ; Recruitment ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA, Viral - genetics ; RNA, Viral - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Viral Proteins - genetics ; Viral Proteins - metabolism</subject><ispartof>PLoS pathogens, 2011-07, Vol.7 (7), p.e1002138-e1002138</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Jackson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Jackson BR, Boyne JR, Noerenberg M, Taylor A, Hautbergue GM, et al. (2011) An Interaction between KSHV ORF57 and UIF Provides mRNA-Adaptor Redundancy in Herpesvirus Intronless mRNA Export. PLoS Pathog 7(7): e1002138. doi:10.1371/journal.ppat.1002138</rights><rights>Jackson et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c660t-cf0aefd32f800cb639bf5bd06f40afb5ef57981854770a7bbf64efb3991d18903</citedby><cites>FETCH-LOGICAL-c660t-cf0aefd32f800cb639bf5bd06f40afb5ef57981854770a7bbf64efb3991d18903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141038/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141038/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21814512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Glaunsinger, Britt A.</contributor><creatorcontrib>Jackson, Brian R</creatorcontrib><creatorcontrib>Boyne, James R</creatorcontrib><creatorcontrib>Noerenberg, Marko</creatorcontrib><creatorcontrib>Taylor, Adam</creatorcontrib><creatorcontrib>Hautbergue, Guillaume M</creatorcontrib><creatorcontrib>Walsh, Matthew J</creatorcontrib><creatorcontrib>Wheat, Rachel</creatorcontrib><creatorcontrib>Blackbourn, David J</creatorcontrib><creatorcontrib>Wilson, Stuart A</creatorcontrib><creatorcontrib>Whitehouse, Adrian</creatorcontrib><title>An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently export Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs from the nucleus, the KSHV ORF57 protein recruits hTREX onto viral intronless mRNAs allowing access to the TAP-mediated export pathway. Similarly however, depletion of Aly only leads to a modest reduction in the nuclear export of KSHV intronless mRNAs. Herein, we identify a novel interaction between ORF57 and the cellular protein, UIF. We provide the first evidence that the ORF57-UIF interaction enables the recruitment of hTREX and TAP to KSHV intronless mRNAs in Aly-depleted cells. Strikingly, depletion of both Aly and UIF inhibits the formation of an ORF57-mediated nuclear export competent ribonucleoprotein particle and consequently prevents ORF57-mediated mRNA nuclear export and KSHV protein production. Importantly, these findings highlight that redundancy exists in the eukaryotic system for certain hTREX components involved in the mRNA nuclear export of intronless KSHV mRNAs.</description><subject>Active Transport, Cell Nucleus - genetics</subject><subject>Biology</subject><subject>Cell Nucleus - genetics</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Nucleus - virology</subject><subject>Colleges & universities</subject><subject>Competition</subject><subject>Experiments</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>HEK293 Cells</subject><subject>Herpesvirus 8, Human - genetics</subject><subject>Herpesvirus 8, Human - metabolism</subject><subject>Herpesviruses</subject><subject>Humans</subject><subject>Messenger RNA</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Properties</subject><subject>Proteins</subject><subject>Recruitment</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Viral - genetics</subject><subject>RNA, Viral - metabolism</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqVklFv0zAUhSMEYmPwDxBE4gHx0OIbJ3HyglRNlFVMm9QxXi3Hvu48pXZmJ2X797hrNq1oL8gPtuzvnOt7dJPkPZApUAZfr93grWinXSf6KRCSAa1eJIdQFHTCKMtfPjkfJG9CuCYkBwrl6-QggwryArLDpJvZ1NgevZC9cTZtsP-DaNOfFye_0_PlvGCpsCq9XMzTzruNURjS9fJsNhFKdL3zqUc1WCWsvIs-6RX6DsPG-CFsbb2zLYadIsXbzvn-bfJKizbgu3E_Si7n338dn0xOz38sjmenE1mWpJ9ITQRqRTNdESKbktaNLhpFSp0ToZsCdcHqCqoiZ4wI1jS6zFE3tK5BQVUTepR83Pl2rQt8DCtwyOJjFTUQicWOUE5c886btfB33AnD7y-cX3HheyNb5EozIRQtpMxjGaaFgjyPCQhCAaQuo9e3sdrQrFFJjL2Lds90_8WaK75yG04hB0KraPB5NPDuZsDQ87UJEttWWHRD4FUFpKozxiL56R_y-eZGaiXi_43VLpaVW08-y0paFjW7D2n6DBWXwrWRzqI28X5P8GVPEJkeb_uVGELgi4vlf7Bn-2y-Y6V3IXjUj9EB4dtxf2iSb8edj-MeZR-exv4oephv-hexxPv3</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Jackson, Brian R</creator><creator>Boyne, James R</creator><creator>Noerenberg, Marko</creator><creator>Taylor, Adam</creator><creator>Hautbergue, Guillaume M</creator><creator>Walsh, Matthew J</creator><creator>Wheat, Rachel</creator><creator>Blackbourn, David J</creator><creator>Wilson, Stuart A</creator><creator>Whitehouse, Adrian</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110701</creationdate><title>An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export</title><author>Jackson, Brian R ; Boyne, James R ; Noerenberg, Marko ; Taylor, Adam ; Hautbergue, Guillaume M ; Walsh, Matthew J ; Wheat, Rachel ; Blackbourn, David J ; Wilson, Stuart A ; Whitehouse, Adrian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c660t-cf0aefd32f800cb639bf5bd06f40afb5ef57981854770a7bbf64efb3991d18903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Active Transport, Cell Nucleus - genetics</topic><topic>Biology</topic><topic>Cell Nucleus - genetics</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Nucleus - virology</topic><topic>Colleges & universities</topic><topic>Competition</topic><topic>Experiments</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>HEK293 Cells</topic><topic>Herpesvirus 8, Human - genetics</topic><topic>Herpesvirus 8, Human - metabolism</topic><topic>Herpesviruses</topic><topic>Humans</topic><topic>Messenger RNA</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Properties</topic><topic>Proteins</topic><topic>Recruitment</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Viral - genetics</topic><topic>RNA, Viral - metabolism</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>Viral Proteins - genetics</topic><topic>Viral Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jackson, Brian R</creatorcontrib><creatorcontrib>Boyne, James R</creatorcontrib><creatorcontrib>Noerenberg, Marko</creatorcontrib><creatorcontrib>Taylor, Adam</creatorcontrib><creatorcontrib>Hautbergue, Guillaume M</creatorcontrib><creatorcontrib>Walsh, Matthew J</creatorcontrib><creatorcontrib>Wheat, Rachel</creatorcontrib><creatorcontrib>Blackbourn, David J</creatorcontrib><creatorcontrib>Wilson, Stuart A</creatorcontrib><creatorcontrib>Whitehouse, Adrian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jackson, Brian R</au><au>Boyne, James R</au><au>Noerenberg, Marko</au><au>Taylor, Adam</au><au>Hautbergue, Guillaume M</au><au>Walsh, Matthew J</au><au>Wheat, Rachel</au><au>Blackbourn, David J</au><au>Wilson, Stuart A</au><au>Whitehouse, Adrian</au><au>Glaunsinger, Britt A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>7</volume><issue>7</issue><spage>e1002138</spage><epage>e1002138</epage><pages>e1002138-e1002138</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>The hTREX complex mediates cellular bulk mRNA nuclear export by recruiting the nuclear export factor, TAP, via a direct interaction with the export adaptor, Aly. Intriguingly however, depletion of Aly only leads to a modest reduction in cellular mRNA nuclear export, suggesting the existence of additional mRNA nuclear export adaptor proteins. In order to efficiently export Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs from the nucleus, the KSHV ORF57 protein recruits hTREX onto viral intronless mRNAs allowing access to the TAP-mediated export pathway. Similarly however, depletion of Aly only leads to a modest reduction in the nuclear export of KSHV intronless mRNAs. Herein, we identify a novel interaction between ORF57 and the cellular protein, UIF. We provide the first evidence that the ORF57-UIF interaction enables the recruitment of hTREX and TAP to KSHV intronless mRNAs in Aly-depleted cells. Strikingly, depletion of both Aly and UIF inhibits the formation of an ORF57-mediated nuclear export competent ribonucleoprotein particle and consequently prevents ORF57-mediated mRNA nuclear export and KSHV protein production. Importantly, these findings highlight that redundancy exists in the eukaryotic system for certain hTREX components involved in the mRNA nuclear export of intronless KSHV mRNAs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21814512</pmid><doi>10.1371/journal.ppat.1002138</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1553-7374 |
ispartof | PLoS pathogens, 2011-07, Vol.7 (7), p.e1002138-e1002138 |
issn | 1553-7374 1553-7366 1553-7374 |
language | eng |
recordid | cdi_plos_journals_1289087701 |
source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
subjects | Active Transport, Cell Nucleus - genetics Biology Cell Nucleus - genetics Cell Nucleus - metabolism Cell Nucleus - virology Colleges & universities Competition Experiments Gene expression Genetic aspects Genetics HEK293 Cells Herpesvirus 8, Human - genetics Herpesvirus 8, Human - metabolism Herpesviruses Humans Messenger RNA Nuclear Proteins - genetics Nuclear Proteins - metabolism Properties Proteins Recruitment RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - genetics RNA, Viral - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Viral Proteins - genetics Viral Proteins - metabolism |
title | An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T21%3A17%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20interaction%20between%20KSHV%20ORF57%20and%20UIF%20provides%20mRNA-adaptor%20redundancy%20in%20herpesvirus%20intronless%20mRNA%20export&rft.jtitle=PLoS%20pathogens&rft.au=Jackson,%20Brian%20R&rft.date=2011-07-01&rft.volume=7&rft.issue=7&rft.spage=e1002138&rft.epage=e1002138&rft.pages=e1002138-e1002138&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.1002138&rft_dat=%3Cgale_plos_%3EA263659790%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1289087701&rft_id=info:pmid/21814512&rft_galeid=A263659790&rft_doaj_id=oai_doaj_org_article_df7aad35cc464e7fad144adaa0311cf6&rfr_iscdi=true |