Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1)

The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions betwee...

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Veröffentlicht in:	PLoS pathogens 2011-08, Vol.7 (8), p.e1002184
Hauptverfasser:	Sakane, Naoki, Kwon, Hye-Sook, Pagans, Sara, Kaehlcke, Katrin, Mizusawa, Yasuhiro, Kamada, Masafumi, Lassen, Kara G, Chan, Jonathan, Greene, Warner C, Schnoelzer, Martina, Ott, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals DNA methylation Epigenesis, Genetic - physiology Epigenetics Experiments Flow cytometry Genes, Viral - drug effects Genetic aspects Genetic transcription Histone Demethylases - antagonists & inhibitors Histone Demethylases - metabolism HIV HIV (Viruses) Human immunodeficiency virus Infections Kinases Lymphocytes Medical research Medicine Methylation Methyltransferases Phenelzine - pharmacology Physiological aspects Positive Transcriptional Elongation Factor B - metabolism Proteins Rabbits tat Gene Products, Human Immunodeficiency Virus - immunology tat Gene Products, Human Immunodeficiency Virus - metabolism Transcription, Genetic - drug effects Viral proteins
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